2597-56-0 Usage
Description
2-Methoxy-4-nitrobenzoic acid, with the CAS number 2597-56-0, is an alkoxybenzoic acid derivative. It is a white to off-white crystalline solid that has been synthesized by reacting 2-hydroxy-4-nitrobenzoic acid with methyl iodide and is characterized by 1H and 13C-NMR spectra.
Uses
Used in Organic Synthesis:
2-Methoxy-4-nitrobenzoic acid is used as a starting material in various organic syntheses for the creation of different chemical compounds.
Used in Pharmaceutical Industry:
2-Methoxy-4-nitrobenzoic acid is used as a starting material for the synthesis of:
1. 2-Methoxy-4-nitrobenzamide, a nitroamide derivative, which may have potential applications in the development of new pharmaceuticals.
2. 4-Amino-2-methoxybenzamide, an aminobenzamide derivative, which could be utilized in the creation of novel drug candidates.
3. N,2-Dimethoxy-N-methyl-4-nitrobenzamide, a Weinreb amide derivative, which might be employed in the synthesis of various bioactive molecules.
4. 1-(2-Methoxy-4-nitrophenyl)-5-methylhex-2-yn-1-one, a ynone derivative, which could be used in the development of new chemical entities.
5. 2,5-Constrained piperidine derivative, a potential CCR3 (Chemokine (C-C Motif) Receptor 3) antagonist, which may have applications in the treatment of various diseases related to the immune system.
Check Digit Verification of cas no
The CAS Registry Mumber 2597-56-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,9 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2597-56:
(6*2)+(5*5)+(4*9)+(3*7)+(2*5)+(1*6)=110
110 % 10 = 0
So 2597-56-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NO5/c1-14-7-4-5(9(12)13)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)
2597-56-0Relevant articles and documents
Synthesis of 2-Methoxy-4-(methylsulfanyl)benzoic Acid — An Intermediate Product in the Preparation of the Cardiotonic Drugs Sulmazole and Isomazole
Lomov
, p. 1093 - 1098 (2019/10/19)
Readily available 4-methyl-3-nitrobenzenesulfonic acid and 2-methyl-5-nitrophenol were used to develop two alternative approaches to the synthesis of 2-methoxy-4-(methylsulfanyl)benzoic acid in total yields of 17% and 37%, respectively. The synthesis starting from 2-methyl-5-nitrophenol is more process-oriented and can be used in the resynthesis of Sulmazole and Isomazole.
Oligophenylenaminones as scaffolds for α-helix mimicry
Adler, Marc J.,Hamilton, Andrew D.
experimental part, p. 7040 - 7047 (2011/10/08)
The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety of biological systems as functional disruptors of α-helix- mediated protein-protein interactions. In our studies we have continued to develop novel, more biologically compatible scaffolds, which are often easier to assemble and capable of mimicking longer and/or more diverse helices. To this end, we have constructed a new series of i, i+4, i+7 α-helix mimics based on the enaminone scaffold. These molecules represent a step forward in the pursuit of idealized monofacial α-helix mimetics.
PRODRUGS OF OPIOIDS AND USES THEREOF
-
, (2011/08/08)
The present invention concerns prodrugs of opioid analgesics and pharmaceutical compositions containing such prodrugs. Methods for providing more consistent pain relief by increasing the bioavailability of the opioid analgesic with the aforementioned prodrugs are provided. The invention also provides for decreasing the adverse GI side effects of opioid analgesics.