2598-46-1Relevant articles and documents
Rationally engineered variants of S-adenosylmethionine (SAM) synthase: Reduced product inhibition and synthesis of artificial cofactor homologues
Dippe,Brandt,Rost,Porzel,Schmidt,Wessjohann
supporting information, p. 3637 - 3640 (2015/03/30)
S-Adenosylmethionine (SAM) synthase was engineered for biocatalytic production of SAM and long-chain analogues by rational re-design. Substitution of two conserved isoleucine residues extended the substrate spectrum of the enzyme to artificial S-alkylhomocysteines. The variants proved to be beneficial in preparative synthesis of SAM (and analogues) due to a much reduced product inhibition. This journal is
A SIMPLE PREPARATION OF S-ALKYL HOMOCYSTEINE DERIVATIVES: S-PHOSPHONOMETHYL HOMOCYSTEINES AS INHIBITORS OF GLUTAMINE SYNTHETASE
Logusch, Eugene W.
, p. 6055 - 6058 (2007/10/02)
A facile synthesis of S-alkyl homocysteines is described which features the coupling of sodium alkyl thiolates with methyl 4-bromo-2-phthalimidobutyrate, followed by hydrolysis.This approach is exemplified by the synthesis of S-phosphonomethyl homocysteine sulfone, a new inhibitor of the enzyme glutamine synthetase.
