259869-55-1

Basic information

• Product Name: (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN
• Synonyms: (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN;JWH 133;(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-(6H)-dibenzo[b.d]pyrane;3-(1,1-Dimethylbutyl)-1-deoxy-Δ8-THC, 3-(1,1-Dimethylbutyl)-1-deoxy-Δ8-tetrahydrocannabinol;JW 133;JWH 133 (in Tocrisolve(TM) 100);JWH 133 (in Tocrisolve 100);6H-Dibenzo[b,d]pyran, 3-(1,1-diMethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-triMethyl-, (6aR,10aR)-
• CAS NO: 259869-55-1
• Molecular Formula: C22H32O
• Molecular Weight: 312.49
• Product Categories: Cannabinoid receptor;Cannabinoids
• Mol File: 259869-55-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 382°C at 760 mmHg
• Flash Point: 182.8°C
• Appearance: /
• Density: 0.95g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: −20°C
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN(CAS DataBase Reference)
• NIST Chemistry Reference: (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN(259869-55-1)
• EPA Substance Registry System: (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN(259869-55-1)

Safety Data

• Hazardous Substances Data: 259869-55-1(Hazardous Substances Data)

Usage

Description

(6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN, also known as JW 133, is a chemical compound that serves as an intermediate in the synthesis of potent CB2-Selective Cannabinoid Receptor Ligands. It is characterized by its unique molecular structure, which includes a tetrahydro-dibenzopyran core with a 1,1-dimethylbutyl group attached to the 3-position.

Uses

Used in Pharmaceutical Industry:
JW 133 is used as an intermediate in the synthesis of CB2-Selective Cannabinoid Receptor Ligands for various therapeutic applications. These ligands, such as 4-oxo-1,4-dihydroquinoline-3-carboxamides and 3-(1'',1''-Dimethylbutyl)-1-deoxy-Δ8-THC analogs, have the potential to modulate the CB2 receptor, which is involved in various physiological processes and may offer therapeutic benefits in treating certain conditions.
Used in Drug Development:
JW 133 plays a crucial role in the development of novel drugs targeting the CB2 receptor. By serving as an intermediate in the synthesis of potent CB2-Selective Cannabinoid Receptor Ligands, JW 133 contributes to the advancement of drug candidates that may have potential applications in treating various diseases and disorders.

Biological Activity

Potent CB 2 selective agonist (K i = 3.4 nM). Approx. 200-fold selective over CB 1 receptors. Active in vivo , reducing spasticity in a murine model of multiple sclerosis. Also available in water soluble emulsion ((6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran ).

InChI:InChI=1/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1