26002-56-2Relevant articles and documents
Synthesis and Reactivity of α-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3
Wu, Jiang,Zhao, Qunchao,Wilson, Thomas C.,Verhoog, Stefan,Lu, Long,Gouverneur, Véronique,Shen, Qilong
supporting information, p. 2413 - 2417 (2019/02/01)
A highly reactive electrophilic bromodifluoromethylthiolating reagent, α-cumyl bromodifluoro-methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluoromethylthiolated arenes. These compounds are amenable to various transformations including halogen exchange with [18F]KF/K222, a process giving access to [18F]arylSCF3 in two steps from the corresponding aryl boronic pinacol esters.