260065-70-1 Usage
Description
Cycloheptanol, 2-amino-, (1R,2R)(9CI) is a chiral organic compound with a cycloheptanol core and an amino group at the 2nd position. It is characterized by its specific stereochemistry, with the 1R,2R configuration, which is crucial for its reactivity and potential applications in various chemical and pharmaceutical processes.
Uses
Used in Pharmaceutical Industry:
Cycloheptanol, 2-amino-, (1R,2R)(9CI) is used as a reactant for the preparation of 4,6-difluoro-N-(1S,2S)-2-hydroxycyclohexyl-1-((6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-yl)methyl)-1H-indole-3-carboxamide. Cycloheptanol, 2-amino-, (1R,2R)(9CI) serves as a potent M1 ago-positive allosteric modulator (PAM), which has potential therapeutic applications in the treatment of various cognitive disorders and neurological conditions. The unique stereochemistry of (1R,2R)-trans-2-aminocyclohexanol plays a vital role in the synthesis and biological activity of the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 260065-70-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,0,0,6 and 5 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 260065-70:
(8*2)+(7*6)+(6*0)+(5*0)+(4*6)+(3*5)+(2*7)+(1*0)=111
111 % 10 = 1
So 260065-70-1 is a valid CAS Registry Number.
260065-70-1Relevant articles and documents
Lipase-catalyzed Kinetic Resolution of (+/-)-trans- and cis-2-Azidocycloalkanols
Ami, Ei'ichi,Ohrui, Hiroshi
, p. 2150 - 2156 (2007/10/03)
The lipase-catalyzed kinetic resolution of trans- and cis-2-azidocycloalkanols and the preparation of enantiomerically pure trans- and cis-2-aminocycloalkanols are described. Four kinds of lipases were screened for the acetylation of trans- and cis-2-azidocycloalkanols. Among them, Pseudomonas sp. lipases (lipase PS and lipase AK, Amamo Pharmaceutical Co.) showed the highest enantioselectivity. These products were converted to the corresponding 2-aminocycloalkanols to determine their enantiomeric excess (ee) and absolute configurations by HPLC and CD analyses, using (S)-TBMB carboxylic acid [(S)-2-tert-butyl-2-methyl-1,3-benzodioxole-4-carboxylic acid] as the chiral conversion reagent. The results of the CD analysis proved N,O-bis-(S)-TBMB carboxylated cis-2-aminocycloalkanols to adopt a predominantly N-equatorial conformation. The partially resolved trans- and cis-2-aminocycloalkanols, except for trans-2-aminocyclopentanol, were recrystallized from ethyl acetate to give enantiomerically pure forms.