2601-07-2Relevant articles and documents
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Marker,Wagner,Wittbecker
, p. 2039,2094 (1942)
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Steroid compound for treating depression
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Paragraph 0074-0076, (2022/01/04)
The invention discloses a novel compound as shown in a general formula 1, a pharmaceutically acceptable salt and solvate of the novel compound, a stereoisomer comprising mixtures of the novel compound in various proportions and a pharmaceutical composition containing the novel compound. In the formula, R1, R2, R3, R4a, R4b, R5, R6a, R6b, R6c, R6d, R6e, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, ring A and the like have meanings given in the specification. The invention also relates to a preparation method of the compound, and also relates to application of the pharmaceutically acceptable salt, solvate and stereoisomer including mixtures in various proportions of the compound, in particular to application in preparation of medicines for protecting, treating, treating or relieving depression.
A practical solution for aqueous reactions of water-insoluble high-melting-point organic substrates
Cui, Xiaoxue,Li, Bo,Liu, Tianzhen,Li, Chunbao
supporting information; experimental part, p. 668 - 672 (2012/06/01)
A practical solution to the problem of performing aqueous reactions for very sparingly soluble high-melting-point (VSSHMP) organic substrates has been developed, which entails mechanically stirring a mixture of the substrate, the corresponding reagent(s), water, catalytic Aliquat 336 and sand. When the melting points of the substrates which include steroids, ketones, aldehydes, aromatics and alkaloids are around 200 °C, the reactions can be performed at 20 °C. The substrate solubility can be as low as 1 × 10-10 mol L-1. The Royal Society of Chemistry 2012.
