260270-95-9

Basic information

• Product Name: tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-4-pentenoate
• Synonyms: tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-4-pentenoate
• CAS NO: 260270-95-9
• Molecular Weight: 319.401
• Mol File: 260270-95-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-4-pentenoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-4-pentenoate(260270-95-9)
• EPA Substance Registry System: tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-4-pentenoate(260270-95-9)

Safety Data

• Hazardous Substances Data: 260270-95-9(Hazardous Substances Data)

Upstream product

• 260270-94-8 (2S,3R)-2-benzyloxycarbonylamino-3-methyl-4-pentenoic acid 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 501-53-1 benzyl chloroformate 
• 249553-80-8 (2S,3R)-(+)-2-Amino-3-methylpent-4-enoic acid 

Downstream Products

• 260270-96-0 tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-5-hydroxy-3-methylpentanoate 
• 383173-92-0 (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-5-({(Z)-(methylsulfanyl)[(methylsulfonyl)imino]methyl}amino)pentanoic acid 
• 260270-97-1 tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-5-azido-3-methylpentanoate 
• 260271-08-7 tert-butyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-5-amino-3-methylpentanoate 

Relevant articles and documents

Enantioselective and Diastereodivergent Access to α-Substituted α-Amino Acids via Dual Iridium and Copper Catalysis

The work reported within this paper describes an example of the application of bimetallic catalysts system in allylic substitution reactions. The development of new nucleophiles and the control of enantio- and diastereoselectivity are the main research topics in this area. An improvement in the reactivity and diastereoselectivity has been realized for the dual Ir/Cu catalyzed allylic alkylation of inactive prochiral nucleophiles, under mild reaction conditions. Furthermore, the choice of the metallacyclic iridium complex and chiral Cu-Phox complex combination allows for access to all four stereoisomers from the same starting materials with excellent enantioselectivity and diastereoselectivity (up to >99% ee and >20:1 dr). Significantly, this method provides a stereodivergent access to 2-amino-3-methylpent-4-acid ester, an important fragment for the synthesis of Halipeptin A. (Figure presented.).

Design of selective and soluble inhibitors of tumor necrosis factor-α converting enzyme (TACE)

A program to improve upon the in vitro, in vivo, and physicochemical properties of N-hydroxyformamide TACE inhibitor GW 3333 (1) is described. Using the primary structure of pro-TNF-α, along with a homology model of the catalytic domain of TACE based on t