26041-51-0

Basic information

• Product Name: N-Acetyl L-Thyroxine
• Synonyms: N-Acetyl L-Thyroxine;N-Acetyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine;N-Acetylthyroxine;Levothyroxine Sodium Impurity E;N-Acetyl-T4;Levothyroxine N-Acetyl Impurity;Levothyroxine Related Compound 5 [N-Acetyl-O-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodo-L-Tyrosine]
• CAS NO: 26041-51-0
• Molecular Formula: C₁₇H₁₃I₄NO₅
• Molecular Weight: 818.9067
• Product Categories: Amino Acids & Derivatives;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 26041-51-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 210-215 °C (decomp)
• Boiling Point: 671.8±55.0 °C(Predicted)
• Appearance: /
• Density: 2.481±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.95±0.10(Predicted)
• CAS DataBase Reference: N-Acetyl L-Thyroxine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl L-Thyroxine(26041-51-0)
• EPA Substance Registry System: N-Acetyl L-Thyroxine(26041-51-0)

Safety Data

• Hazardous Substances Data: 26041-51-0(Hazardous Substances Data)

Usage

Description

N-Acetyl L-Thyroxine, also known as the Thyroxine analogue, is a synthetic thyroid hormone derived from the naturally occurring hormone thyroxine. It is a white solid substance with unique chemical properties that make it suitable for various applications in the medical field.

Uses

Used in Pharmaceutical Industry:
N-Acetyl L-Thyroxine is used as a diagnostic agent for identifying and monitoring thyroid function in patients. Its application reason is based on its ability to mimic the effects of the natural thyroid hormone, allowing for accurate assessment of thyroid-related conditions.
Used in Endocrinology:
N-Acetyl L-Thyroxine is used as a therapeutic agent for treating diabetes, particularly in cases where thyroid hormone levels need to be regulated. The application reason is its role in maintaining proper metabolic function and glucose homeostasis, which is crucial for managing diabetes.
Used in Diagnostic Applications:
N-Acetyl L-Thyroxine is used as a diagnostic aid in the detection and evaluation of thyroid disorders. The application reason is its structural similarity to the natural thyroid hormone, which allows for the assessment of the body's response to the synthetic analogue, providing valuable information about thyroid function and potential dysfunction.

Upstream product

• 1027-28-7 N-acetyl-3,5-diiodo-L-tyrosine 
• 96679-34-4 3.5-diiodo-N.O-diacetyl-L-tyrosine 
• 51-48-9 L-thyroxine 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 75937-15-4 C₂₁H₁₆I₄N₂O₇ 

Relevant articles and documents

Preparation method of hapten acetyl iodothyroxine active coupling reagent

The invention discloses a preparation method of a hapten acetyl iodothyroxine active coupling reagent. The preparation method comprises the following steps: preparing acetic acid active ester; subjecting the prepared acetic acid active ester to reacting with iodothyroxine to synthesize an intermediate compound 1; and subjecting the intermediate compound 1 to reacting with N-hydroxysuccinimide and a condensing agent to synthesize the hapten acetyl iodothyroxine active coupling reagent. The preparation method has the advantages of low price and easy availability of raw materials, few synthesis steps, simplicity in operation, convenience in extraction and purification and high yield, provides a brand new solution for synthesizing the hapten acetyl iodothyroxine active coupling reagent, and overcomes problems in synthesis of artificial antigen key raw materials during preparation of monoclonal antibodies from micromolecule haptens and in synthesis of key raw materials in development of kits for clinical detection of thyroid function items.

Novel derivatives of thyroid hormone and use of thereof

The present invention relates to: a thyroid hormone derivative or a pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of diseases of the brain and nervous system due to dopamine deficiency, containing the same as an active ingredient; and a method for treating diseases of the brain and nervous system caused by dopamine deficiency. The thyroid hormone derivative according to the present invention can promote the differentiation of neural progenitors into dopamine neurons like thyroid hormones, while lowering the risk of hyperthyroidism by repeated administration, and thus, can be useful for the prevention and treatment of diseases of the brain and nervous system due to dopamine deficiency, including Parkinsonandprime;s disease. A compound or a pharmaceutically acceptable salt thereof is represented by chemical formula 1.COPYRIGHT KIPO 2020

Reagents and methods for the detection and quantification of thyroxine in fluid samples

Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: STR1 wherein P is an immunogenic carrier material and X is a linking moiety. The present invention also describes the synthesis of unique labelled reagent of the formula: STR2 wherein Q is a detectable moiety and W is a linking moiety, preferably fluorescein or a fluorescein derivative.