260784-21-2 Usage
Description
5-(2-carboxymethoxy-1-naphthylmethylene)-4-oxo-2-thioxothiazolidine is a chemical compound with a complex structure that features a thiazolidine ring, a naphthalene group, and a carboxylic acid functional group. This molecule is characterized by its potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
5-(2-carboxymethoxy-1-naphthylmethylene)-4-oxo-2-thioxothiazolidine is used as a key intermediate in the synthesis of new drugs for biological activities. Its application is particularly relevant in the development of aldose reductase inhibitors, which are important for managing diabetic complications.
Used in Chemical Research:
In the field of chemical research, 5-(2-carboxymethoxy-1-naphthylmethylene)-4-oxo-2-thioxothiazolidine serves as a valuable compound for exploring novel chemical reactions and understanding the reactivity of its functional groups. This can lead to the discovery of new synthetic pathways and the development of additional applications in various industries.
Used in Material Science:
The unique structure of 5-(2-carboxymethoxy-1-naphthylmethylene)-4-oxo-2-thioxothiazolidine may also find applications in material science, where it could be used to develop new materials with specific properties, such as improved stability or enhanced biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 260784-21-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,0,7,8 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 260784-21:
(8*2)+(7*6)+(6*0)+(5*7)+(4*8)+(3*4)+(2*2)+(1*1)=142
142 % 10 = 2
So 260784-21-2 is a valid CAS Registry Number.
260784-21-2Relevant articles and documents
Synthesis and aldose reductase inhibitory activity of a new series of 5- [[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives
Murata, Makoto,Fujitani, Buichi,Mizuta, Hiroyuki
, p. 1061 - 1070 (2007/10/03)
A new series of 5-[[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2- thioxothiazolidine derivatives was synthesized and evaluated for their potency as aldose reductase inhibitors (ARIs). Their activities were examined in terms of their inhibitory effect on rat lens aldose reductase in vitro and in terms of the preventive effect on sorbitol accumulation in the sciatic nerve of streptozotocin (STZ)-induced diabetic rats in vivo. Of these compounds, some of the naphthylmethylene thiazolidine derivatives were comparable to Zenarestat in the inhibitory potency in vitro and in vivo. In particular, compound 30 was 1.5 times more potent than Zenarestat in the in vivo activity, and had an adequate potency for clinical development.
