260968-52-3

Basic information

• Product Name: 6-(biphenyl-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• Synonyms: 6-(biphenyl-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• CAS NO: 260968-52-3
• Molecular Weight: 280.35
• Mol File: 260968-52-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(biphenyl-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(biphenyl-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(260968-52-3)
• EPA Substance Registry System: 6-(biphenyl-4-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(260968-52-3)

Safety Data

• Hazardous Substances Data: 260968-52-3(Hazardous Substances Data)

Upstream product

• 17356-08-0 thiourea 
• 57477-98-2 3-biphenyl-4-yl-3-oxopropionic acid ethyl ester 

Downstream Products

• 1023694-73-6 ethyl 5-(4-(biphenyl-4-yl)-6-oxo-1,6-dihydropyrimidin-2-ylthio)pentanoate 
• 1023694-77-0 C₂₆H₂₂N₂O₃S 

Relevant articles and documents

Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities

A novel series of non-hydroxamate HDAC inhibitors (HDACi) showing a uracil group at the left and a 2-aminoanilide/2-aminoanilide-like portion at the right head have been reported. In particular, the new compounds incorporating a 2-aminoanilide moiety behaved as class I-selective HDACi. Compound 8, the most potent and class I-selective, showed weak apoptosis (higher than MS-275) joined to cytodifferentiating activity on U937 cells. Surprisingly, the highest differentiation was observed with 13, through an effect that seems to be unrelated to HDAC inhibition.