26097-80-3 Usage
Description
Cambendazol, also known as Camdan, is an antihelmintic compound that effectively targets and eradicates parasitic worms, particularly S. ratti adult worms from the intestine and S. stercoralis larvae from muscle tissues. It achieves this by inhibiting the polymerization of microtubules isolated from bovine brain, with an IC50 value of 64.2 μM. This property makes it a promising candidate for the treatment of strongyloidiasis in humans and a potential chemotherapeutic agent.
Uses
Used in Pharmaceutical Industry:
Cambendazol is used as an antihelmintic agent for the treatment of strongyloidiasis in humans. It is effective in eradicating parasitic worms from the intestine and muscle tissues, providing relief from the symptoms and complications associated with the infection.
Used in Research and Development:
Cambendazol is used as a potential chemotherapeutic agent in the development of new treatments for parasitic infections. Its ability to inhibit microtubule polymerization makes it a valuable tool in studying the mechanisms of action and potential applications in combating various parasitic diseases.
Brand Name:
Cambendazol is marketed under the brand name Camdan by Merck, a leading pharmaceutical company. This brand name is associated with the quality and efficacy of the antihelmintic compound, ensuring patients receive a reliable and effective treatment option for strongyloidiasis.
Check Digit Verification of cas no
The CAS Registry Mumber 26097-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,0,9 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 26097-80:
(7*2)+(6*6)+(5*0)+(4*9)+(3*7)+(2*8)+(1*0)=123
123 % 10 = 3
So 26097-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)
26097-80-3Relevant articles and documents
Selective Functionalization of 2-Nitro-p-phenylenediamine : Part III - A New Route to 1-Arylbenzimidazole 5-carbamates, Including Cambendazole
Rajappa, S.,Sreenivasan, R.
, p. 539 - 541 (2007/10/02)
Reaction of 3,4-diaminophenylcarbamic acid ethyl ester (2) with carboxymethyl dithiobenzoate (3) gives the thiobenzanilides (4a or 4b), which could be cyclized by acid to 2-phenylbenzimidazole-5-carbamic acid ethyl ester (5).The same product is obtained by the reaction of 2 with benzaldehyde and sulphur.Other aromatic aldehydes have been similarly reacted to give (9b-d).Cambendazole (9e) is obtained by the reaction of thiazole-4-aldehyde and sulphur with 3,4-diaminophenylcarbamic acid isopropyl ester (6e).
A new broad-spectrum anthelmintic: 2-(4-thiazolyl)-5-isopropoxycarbonylamino-benzimidazole.
Hoff,Fisher,Bochis,Lusi,Waksmunski,Egerton,Yakstis,Cuckler,Campbell
, p. 550 - 551 (2007/10/05)
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