26103-49-1

Basic information

• Product Name: 3-(Piperidin-1-ylsulphonyl)pyridine
• Synonyms: 1-(Pyridin-3-ylsulphonyl)piperidine;3-(Piperidin-1-ylsulphonyl)pyridine;3-(1-Piperidinylsulfonyl)pyridine;3-(Piperidin-1-ylsulphonyl)pyridine 98%;1-(Pyridin-3-ylsulfonyl)piperidine;3-(Piperidin-1-ylsulfonyl)pyridine;3-(Piperidin-1-ylsulphonyl)pyridine98%
• CAS NO: 26103-49-1
• Molecular Formula: C₁₀H₁₄N₂O₂S
• Molecular Weight: 226.29536
• Product Categories: blocks;Pyridines;Sulfonamides
• Mol File: 26103-49-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 88-89 °C
• Boiling Point: 381.3 °C at 760 mmHg
• Flash Point: 184.4 °C
• Appearance: /
• Density: 1.271 g/cm³
• Vapor Pressure: 5.13E-06mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• PKA: 3.07±0.11(Predicted)
• CAS DataBase Reference: 3-(Piperidin-1-ylsulphonyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Piperidin-1-ylsulphonyl)pyridine(26103-49-1)
• EPA Substance Registry System: 3-(Piperidin-1-ylsulphonyl)pyridine(26103-49-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 26103-49-1(Hazardous Substances Data)

Usage

General Description

3-(Piperidin-1-ylsulphonyl)pyridine, also known as PPS, is a chemical compound with the molecular formula C11H16N2O2S. It is a sulphonylpyridine derivative that has been used as a building block in organic synthesis and medicinal chemistry. PPS has been investigated for its potential pharmacological properties, including its ability to act as a serotonin receptor antagonist and to inhibit the enzyme poly(ADP-ribose) polymerase. 3-(Piperidin-1-ylsulphonyl)pyridine has also been studied for its potential use in the treatment of various diseases and conditions, including cancer, inflammatory disorders, and neurodegenerative diseases. Overall, PPS is a versatile chemical with potential applications in both research and medicine.

InChI:InChI=1/C10H14N2O2S/c13-15(14,10-5-4-6-11-9-10)12-7-2-1-3-8-12/h4-6,9H,1-3,7-8H2

Upstream product

• 110-89-4 piperidine 
• 16133-25-8 Pyridine-3-sulfonyl chloride 
• 678173-43-8 1-(3-pyridylsulfonyl)-1H-1,2,3-benzotriazole 
• 60573-68-4 3-pyridyllithium 
• 636-73-7 3-pyridinesulfonic acid 
• 1120-90-7 3-iodopyridine 

Downstream Products

• 88184-87-6 Phenyl-[3-(piperidine-1-sulfonyl)-pyridin-4-yl]-methanol 
• 88184-90-1 Diphenyl-[3-(piperidine-1-sulfonyl)-pyridin-4-yl]-methanol 
• 88184-91-2 (2-Methoxy-phenyl)-[3-(piperidine-1-sulfonyl)-pyridin-4-yl]-methanol 
• 88184-89-8 4-Phenylsulfanyl-3-(piperidine-1-sulfonyl)-pyridine 
• 88184-96-7 Phenyl-[3-(piperidine-1-sulfonyl)-pyridin-4-yl]-methanone 

Relevant articles and documents

Palladium-catalyzed sulfination of aryl and heteroaryl halides: Direct access to sulfones and sulfonamides

A novel palladium-catalyzed sulfination of aryl and heteroaryl halides is described. This reaction operates under mild conditions and provides access to a wide range of aryl and heteroaryl sulfinates, a useful and versatile class of synthetic intermediates. Capitalizing on this sulfination reaction, one-pot protocols allowing direct access to sulfones and sulfonamides have also been developed. The practicality of these transformations is illustrated with the parallel synthesis of analogues of the drug Viagra.

Regioselective Lithiation of 3-Pyridylsulfonic Acid Derivatives: A Convenient Route to Various New 4-Substituted 3-Pyridylsulfonamides

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