26107-35-7

Basic information

• Product Name: 2,5-diphenyl-4-(p-tolyl)oxazole
• Synonyms: 2,5-diphenyl-4-(p-tolyl)oxazole
• CAS NO: 26107-35-7
• Molecular Weight: 311.383
• Mol File: 26107-35-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,5-diphenyl-4-(p-tolyl)oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-diphenyl-4-(p-tolyl)oxazole(26107-35-7)
• EPA Substance Registry System: 2,5-diphenyl-4-(p-tolyl)oxazole(26107-35-7)

Safety Data

• Hazardous Substances Data: 26107-35-7(Hazardous Substances Data)

Upstream product

• 613-90-1 benzoyl cyanide 
• 100-52-7 benzaldehyde 
• 4242-46-0 1-cyanobenzyl benzoate 
• 108-88-3 toluene 
• 92-71-7 2,5-diphenyloxazole 
• 106-38-7 para-bromotoluene 
• 1629159-50-7 2-phenyl-3-(p-tolyl)-2H-azirine 
• 55-21-0 benzamide 
• 2166-87-2 2-benzoylamino-2-hydroxy-1-phenyl-ethanone 
• 1074-12-0 phenylglyoxal hydrate 
• 135120-37-5 N-(2-oxo-2-phenyl-1-(p-tolyl)ethyl)benzamide 

Relevant articles and documents

Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsymmetrical Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The results demonstrated that the utilization of this "unsymmetrical"strategy led to much higher efficiency in comparison to the commonly used C2-symmetric Pd-PEPPSI-type NHC complexes. Furthermore, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at as low as 0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with our study, we also found that the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

[3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H-Azirines and Aldehydes

A novel [3 + 2] cycloaddition/oxidative aromatization sequence via visible light-induced photoredox catalysis is disclosed. It provides a general synthetic route to 2,4,5-trisubstituted oxazoles from easily accessible 2H-azirines and aldehydes under mild reaction conditions. The potential of this strategy was further demonstrated by the rapid synthesis of a cyclooxygenase-2 inhibitor as well as the success of employing electron-deficient alkenes and imines as the reaction partners.