261178-91-0

Basic information

• Product Name: C₂₃H₂₇N₃O₂
• Synonyms: C₂₃H₂₇N₃O₂
• CAS NO: 261178-91-0
• Molecular Weight: 377.486
• Mol File: 261178-91-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇N₃O₂(261178-91-0)
• EPA Substance Registry System: C₂₃H₂₇N₃O₂(261178-91-0)

Safety Data

• Hazardous Substances Data: 261178-91-0(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 4950-65-6 cinnamoyl-L-phenylalanine 

Relevant articles and documents

Amino acid and peptide derivatives as antiallergic and anti-inflammatory agents

It was proved that current anti-allergic drugs comprise piperazine - and acrylic acid segments. These compounds were structurally designed as 5-lipoxygenase inhibitors depending on two action mechanisms of the ready drugs used to treat allergy e.g. (Oxatomide), which contains piperazine moiety, its anti-allergic effects possess antagonist activities against chemical mediators such as histamine, Serotonine and leukotriencs (which cause allergy). Also, (Tranilast), which contains acrylic acid segment; its activity depends on inhibition of mediator release. In harmony with these findings new structures having anti-allergic properties are proposed in this manuscript. New products, (5a-u) with expected better biological activities and decreased side effects were synthesized by the addition of an amino acid conjugate of cinnamic acid to a piperazine segment. Their antiallergic and anti-inflammatory activities were evaluated. Most of them show promising activities.