261364-71-0Relevant articles and documents
Drug delivery systems based on trimethyl lock lactonization: Poly(ethylene glycol) prodrugs of amino-containing compounds
Greenwald, Richard B.,Choe, Yun H.,Conover, Charles D.,Shum, Kwok,Wu, Dechun,Royzen, Maksim
, p. 475 - 487 (2007/10/03)
A novel methodology for the synthesis of poly(ethylene glycol) (PEG) prodrugs of amino-containing compounds has been developed which is based on the trimethyl lock lactonization reaction. These PEG-modified double prodrugs are water soluble, and by select