2614-49-5Relevant articles and documents
Acetylcholinesterase inhibition by fused dihydroquinazoline compounds
Jaen, Juan C.,Gregor, Vlad E.,Lee, Chet,Davis, Robert,Emmerling, Mark
, p. 737 - 742 (2007/10/03)
A new type of dihydroquinazoline-based inibitor of acetylcholinesterase (AChE) is described. These compounds were designed to interact with the catalytic site of AChE in a manner similar to the known inhibitor tacrine. In a manner analogous to the potency enhancement obtained by addition of chlorine atoms to the tacrine molecule, a 3-chloro derivative of the parent hexahydroazepino[2,1-b]quinazoline structure was found to be about 8 times more potent as an AChE inhibitor than the unsubstituted compound.