261518-54-1

Basic information

• Product Name: C₅₅H₉₉N₇O₂₄S
• Synonyms: C₅₅H₉₉N₇O₂₄S
• CAS NO: 261518-54-1
• Molecular Weight: 1274.49
• Mol File: 261518-54-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: C₅₅H₉₉N₇O₂₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₅H₉₉N₇O₂₄S(261518-54-1)
• EPA Substance Registry System: C₅₅H₉₉N₇O₂₄S(261518-54-1)

Safety Data

• Hazardous Substances Data: 261518-54-1(Hazardous Substances Data)

Upstream product

• 156-57-0 2-mercaptoethylamine hydrochloride 
• 241820-93-9 1,3,2′,6′,2?,6?-hexa-N-(tert-butoxycarbonyl)-5″-O-(2,4,6-triisopropylbenzenesulfonyl)-neomycin 
• 60-23-1 Cysteamine 

Downstream Products

• 1304127-05-6 C₁₁₈H₂₁₀N₁₆O₅₀S₄ 
• 1058592-96-3 C₇₆H₁₁₅N₁₀O₂₅S⁽¹⁺⁾*Cl^(1-) 

Relevant articles and documents

Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA

Recognition of nucleic acids remains an important endeavor in biology. Nucleic acids adopt shapes ranging from A-form (RNA and GC rich DNA) to B-form (AT rich DNA). We show, in this contribution, shape-specific recognition of A-U rich RNA duplex by a neomycin (Neo)-polydiacetylene (PDA) complex. PDA assemblies are fabricated by using a well-known diacetylene (DA) monomer, 10,12-pentacosadiynoic acid (PCDA). The response of poly(PCDA) assemblies is generated by mixing with a modified neomycin-PCDA monomer (Neo-PCDA). The functionalization by neomycin moiety provides specific binding with homopolyribonucleotide poly(rA)-poly(rU) stimulus. Various types of alcohols are utilized as additives to enhance the sensitivity of poly(PCDA)/Neo-PCDA assemblies. A change of absorption spectra is clearly observed when a relatively low concentration of poly(rA)-poly(rU) is added into the system. Furthermore, poly(PCDA)/Neo-PCDA shows a clear specificity for poly(rA)-poly(rU) over the corresponding DNA duplex. The variation of linker between neomycin moiety and conjugated PDA backbone is found to significantly affect its sensitivity. We also investigate other parameters including the concentration of Neo-PCDA and the DA monomer structure. Our results provide here preliminary data for an alternative approach to improve the sensitivity of PDA utilized in biosensing and diagnostic applications.

Methods and compositions related to viral inhibition

Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.

Probing the recognition surface of a DNA triplex: Binding studies with intercalator-neomycin conjugates

Thermodynamic studies on the interactions between intercalator-neomycin conjugates and a DNA polynucleotide triplex [poly(dA)·2poly(dT)] were conducted. To draw a complete picture of such interactions, naphthalene diimide-neomycin (3) and anthraquinone-ne