26155-38-4

Basic information

• Product Name: 1-methylsulfanyl-N-(1-phenylethylideneamino)methanethioamide
• Synonyms: 1-methylsulfanyl-N-(1-phenylethylideneamino)methanethioamide
• CAS NO: 26155-38-4
• Molecular Formula: C₁₀H₁₂N₂S₂
• Molecular Weight: 224.35
• Mol File: 26155-38-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 333.1°Cat760mmHg
• Flash Point: 155.3°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.000139mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 1-methylsulfanyl-N-(1-phenylethylideneamino)methanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylsulfanyl-N-(1-phenylethylideneamino)methanethioamide(26155-38-4)
• EPA Substance Registry System: 1-methylsulfanyl-N-(1-phenylethylideneamino)methanethioamide(26155-38-4)

Safety Data

• Hazardous Substances Data: 26155-38-4(Hazardous Substances Data)

Usage

Thioamide derivative

A class of compounds PESDMA belongs to this class of compounds, which are characterized by a sulfur atom bound to an amide group.

Methylsulfanyl group

A sulfur atom bound to a methyl group This functional group is present in PESDMA, contributing to its chemical properties and reactivity.

N-(1-phenylethylideneamino) group

A nitrogen atom connected to a 1-phenylethylidene moiety This group is responsible for the compound's potential medicinal properties and reactivity in organic synthesis.

Reagent in organic synthesis

PESDMA is used as a reagent This means that it is a chemical substance that is used to carry out chemical reactions, facilitating the formation of new compounds.

Potential medicinal properties

PESDMA has been studied for its health benefits This indicates that the compound may have therapeutic uses, such as treating diseases or medical conditions.

Anti-cancer agent

PESDMA has shown potential in fighting cancer This suggests that the compound may be able to inhibit or prevent the growth of cancer cells.

Antimicrobial properties

PESDMA can combat microorganisms This means that the compound has the ability to kill or inhibit the growth of bacteria, fungi, or other microorganisms.

Antioxidant properties

PESDMA can neutralize harmful free radicals This indicates that the compound has the potential to protect cells from damage caused by oxidative stress.

Tyrosinase inhibitor

PESDMA can inhibit the enzyme tyrosinase This suggests that the compound may be able to regulate the production of melanin, which is responsible for skin pigmentation. This property could have applications in the treatment of skin conditions or cosmetic products.

InChI:InChI=1/C10H12N2S2/c1-8(11-12-10(13)14-2)9-6-4-3-5-7-9/h3-7H,1-2H3,(H,12,13)

Upstream product

• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 98-86-2 acetophenone 
• 75-15-0 carbon disulfide 
• 74-88-4 methyl iodide 

Downstream Products

• 108901-66-2 acetophenone morpholine-N-thiohydrazone 
• 13284-51-0 Acetophenon-4-(α-Methyl-δ-diaethylaminobutyl)thiosemicarbazon 
• 132856-24-7 N⁴-(2-aminophenyl)-2-(1-phenylethylidene)hydrazinecarbothioamide 
• 97483-65-3 N-(1,3-Dimethyl-tetrahydro-pyrimidin-2-ylidene)-N'-[1-phenyl-eth-(E)-ylidene]-hydrazine 
• 97483-64-2 N-(1,3-Dimethyl-imidazolidin-2-ylidene)-N'-[1-phenyl-eth-(E)-ylidene]-hydrazine 
• 97509-74-5 N-(5,5-Dimethyl-tetrahydro-pyrimidin-2-ylidene)-N'-[1-phenyl-eth-(E)-ylidene]-hydrazine 
• 97483-72-2 C₂₃H₃₀N₆S₂ 
• 84569-50-6 C₂₀H₂₂N₄S₄ 

Relevant articles and documents

Synthesis antimicrobial and anticancer activity of N′- arylmethylidene-piperazine-1-carbothiohydrazide

Ten newly synthesized thiosemicarbazones of piperazine (3a-3j) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pathogenic strains of Vibrio cholerae, protease, Candida albicans and Aspergillus niger. All the 10 compounds (3a-3j) were found to be better than Ciprofloxacin against B. subtilis and four molecules (3c, 3d, 3e, and 3h) against S. aureus. Compound 3j, a derivative of benzophenone, has been identified as a potent and promising candidate against C. albicans. The compounds were also evaluated for their anticancer activity against HBL-100 and HL60 cell lines. Compound 3a, a p-hydroxy benzaldehyde derivative, has been identified as a potent and promising candidate.

Synthesis and anticancer activity of thiosemicarbazones

Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC 50 of compound III-16 against SGC-7901 reaches to 0.032 μM.

A Homologation of Aldehydes and Ketones via the Formation and the Subsequent Pummerer-type Ring Fission of 2-Methylsulfinyl-5,6-dihydro-4H-1,3,4-thiadiazine Derivatives

A two-carbon homologation of aldehydes and ketones was achieved by using a sequence involving the formation and the subsequent Pummerer-type ring fission of 5,6-dihydro-4H-1,3,4-thiadiazine rings possessing methylsulfinyl functionality at C-2.