2617-79-0

Basic information

• Product Name: N-(4-CHLOROPHENYL)FORMAMIDE
• Synonyms: n-(4-chlorophenyl)-formamid;n-(p-chlorophenyl)formamide;p-chlorfenylamidkyselinymravenci;p-chloroformanilide;1-CHLORO-4-FORMAMIDOBENZENE;4'-CHLOROFORMANILIDE;TIMTEC-BB SBB004024;N-(4-CHLOROPHENYL)FORMAMIDE
• CAS NO: 2617-79-0
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• Mol File: 2617-79-0.mol
• Article Data: 188

Chemical Properties

• Melting Point: 101-105 °C(lit.)
• Boiling Point: 314.9°Cat760mmHg
• Flash Point: 144.2°C
• Appearance: /
• Density: 1.316g/cm³
• Vapor Pressure: 0.000453mmHg at 25°C
• Refractive Index: 1.609
• Solubility: soluble in Methanol
• PKA: 14.13±0.70(Predicted)
• CAS DataBase Reference: N-(4-CHLOROPHENYL)FORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-CHLOROPHENYL)FORMAMIDE(2617-79-0)
• EPA Substance Registry System: N-(4-CHLOROPHENYL)FORMAMIDE(2617-79-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: LQ4666000
• Hazardous Substances Data: 2617-79-0(Hazardous Substances Data)

Usage

General Description

N-(4-CHLOROPHENYL)FORMAMIDE, also known as 4-chlorobenzyl formamide, is an organic compound with the molecular formula C7H6ClNO. It is a white solid that is commonly used in the synthesis of pharmaceuticals, agrochemicals, and dyes. This chemical is classified as a formamide, which is a derivative of formic acid. N-(4-CHLOROPHENYL)FORMAMIDE has a variety of applications in the chemical industry, including as a building block in the production of other organic compounds. It is important to handle this chemical with care, as it can be toxic if ingested or inhaled, and can cause skin and eye irritation.

InChI:InChI=1/C7H6ClNO/c8-6-1-3-7(4-2-6)9-5-10/h1-5H,(H,9,10)

Upstream product

• 42910-17-8 N-chloro formanilide 
• 64-18-6 formic acid 
• 106-47-8 4-chloro-aniline 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 103-70-8 Formanilid 
• 65488-28-0 C₁₃H₂₀ClNOSi 
• 109-94-4 formic acid ethyl ester 
• 7549-99-7 1-[N-(4-chloro-phenyl)-formimidoyl]-pyrrolidine 
• 10570-46-4 (4-chloro-benzoyl)-phosphonic acid diethyl ester 
• 6831-82-9 potassium isopropoxide 
• 91851-05-7 2-<(4-chlorophenyl)amino>-2-methoxy-1-phenylethanone 
• 1885-81-0 p-chlorophenyl isocyanide 
• 18197-22-3 N-formylformamide 
• 10535-67-8 trimethylacetic formic anhydride 

Downstream Products

• 1885-81-0 p-chlorophenyl isocyanide 
• 24122-31-4 3-(4-chlorophenyl)quinazolin-4(3H)-one 
• 96313-70-1 4-Chlor-phenylimino-kohlensaeure-thiopentachlorphenylester-chlorid 
• 2771-67-7 N-dichloromethylene-4-chloroaniline 
• 104093-45-0 2H-2-(4-chlorophenyl)benzo[d]-1,2,3-triazole 1-oxide 
• 20304-86-3 5-methyl-benzo[1,2,5]oxadiazole 
• 105946-26-7 2-(4-chloro-phenyl)-6-methyl-2H-benzotriazole-1-oxide 
• 105946-23-4 2-(4-Chlorphenyl)-5-methyl-2H-benzotriazol-1-oxid 
• 2621-80-9 ethyl p-chlorophenylcarbamate 
• 2866-82-2 N-(4-chlorophenyl)benzamide 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 106-47-8 4-chloro-aniline 
• 1219-99-4 N,N'-bis(4-chlorophenyl)urea 
• 26060-33-3 N-(4-chlorophenyl)methanethioamide 

Relevant articles and documents

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Access to α,α-dihaloacetophenones through anodic C[dbnd]C bond cleavage in enaminones

We have developed a method to synthesize α,α-dihaloketones under electrochemical conditions. In this reaction, the Cl- or Br- is oxidized to Cl2 or Br2 at the anode, which undergoes two-step addition reactions with the N,N-dimethyl enaminone, and finally breaks C[dbnd]C of the N,N-dimethyl enaminone to generate α,α-dihaloketones. The electrosynthesis reaction can be conveniently carried out in an undivided electrolytic cell at room temperature. In addition, various functional groups are compatible with this green protocol which can be applied simultaneously to the gram scale without significantly lower yield.

Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents

Two series of novel 4-phenoxypyridine derivatives containing imidazole-4-carboxamide and 4-methyl-5-oxo-4,5-dihydro-1,2,4-triazole-3-carboxamide moieties were synthesized and evaluated for their in vitro inhibitory activities against c-Met kinase and anti

Copper-Catalyzed Cascade N-Dealkylation/N-Methyl Oxidation of Aromatic Amines by Using TEMPO and Oxygen as Oxidants

A novel tandem N-dealkylation and N-methyl aerobic oxidation of tertiary aromatic amines to N-arylformamides using copper and TEMPO has been developed. This methodology suggested an alternative synthetic route from N-methylarylamines to N-arylformamides.