26171-22-2

Basic information

• Product Name: 1H-Pyrrole-2-acetonitrile, 1-methyl-5-(4-methylbenzoyl)-
• CAS NO: 26171-22-2
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• Mol File: 26171-22-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2-acetonitrile, 1-methyl-5-(4-methylbenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-acetonitrile, 1-methyl-5-(4-methylbenzoyl)-(26171-22-2)
• EPA Substance Registry System: 1H-Pyrrole-2-acetonitrile, 1-methyl-5-(4-methylbenzoyl)-(26171-22-2)

Safety Data

• Hazardous Substances Data: 26171-22-2(Hazardous Substances Data)

Upstream product

• 24437-41-0 1-methyl-2-pyrroleacetonitrile 
• 14271-73-9 4-methylbenzoyl cyanide 
• 62128-31-8 (1-methyl-1H-pyrrol-2-yl)-p-tolylmethanone 
• 75-05-8 acetonitrile 
• 874-60-2 4-methyl-benzoyl chloride 
• 56341-36-7 1,5-dimethyl-1H-pyrrole-2-carbonitrile 
• 52728-54-8 1,1-dimethyl-2-n-propylhydrazine 
• 52074-59-6 5-cyanomethyl-1-methyl-pyrrole-2-carbonyl chloride 
• 17310-31-5 di-p-tolyl-cadmium 
• 10108-64-2 cadmium(II) chloride 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 75820-72-3 1-metil-5-p-metilbenzoil-1H-pirrolo-2-carbossialdeide 

Downstream Products

• 26171-23-3 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid 

Relevant articles and documents

Radical-promoted site-specific cross dehydrogenative coupling of heterocycles with nitriles

A first free-radical triggered site-specific cross dehydrogenative coupling reaction of heterocycles with simple nitriles is developed. It allows efficient and facile access to various C-2 cyanoalkylated furans, thiophenes, indoles, and pyrroles. The extremely high selectivities in this case indicate that functionalization of an inert C-H bond could be well-controlled by radical initiation.

Simple synthetic approach to arylacetic NSAIAs via TosMIC procedure

Preparation of 1-methylpyrrole-2-acetonitrile, 1-methyl-5-(4-methylbenzoyl) pyrrole-2-acetonitrile and 2-(6-methoxy-2-naphthyl)propionitrile by treatment of 1-methylpyrrole-2-carboxaldehyde, 1-methyl-5-(4-methylbenzoyl)pyrrole-2-carboxaldehyde and, respectively, 6-methoxy-2-acetylnaphthalene with tosylmethylisocyanide (TosMIC) is described. This one-step synthetic procedure is very useful to obtain the nitrile precursors of tolmetin and naproxen, two clinically important non-steroidal antiinflammatory agents (NSAIAs).

Preparation of 5-aroyl-pyrrole compounds

A process for acylating pyrrole compounds comprising reacting an aroyl halide with the pyrrole compound in the presence of an alkyl aluminum halide. Such acylated pyrrole derivatives are useful as intermediates for the preparation of anti-inflammatory agents and as synthetic intermediates.