261723-33-5

Basic information

• Product Name: (2-BROMO-6-FLUOROPHENYL)METHANOL
• Synonyms: (2-BROMO-6-FLUOROPHENYL)METHANOL;2-bromo-6-fluoroBenzenemethanol;6-Bromo-2-fluorobenzyl alcohol;2-Bromo-6-fluorobenzyl alcohol;BenzeneMethanol, 2-broMo-6-fluoro-
• CAS NO: 261723-33-5
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.03
• Mol File: 261723-33-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 256.7±25.0 °C(Predicted)
• Appearance: /
• Density: 1.658±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.47±0.10(Predicted)
• CAS DataBase Reference: (2-BROMO-6-FLUOROPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BROMO-6-FLUOROPHENYL)METHANOL(261723-33-5)
• EPA Substance Registry System: (2-BROMO-6-FLUOROPHENYL)METHANOL(261723-33-5)

Safety Data

• Hazardous Substances Data: 261723-33-5(Hazardous Substances Data)

Usage

General Description

"(2-Bromo-6-fluorophenyl)methanol" is a chemical compound that comes under the class of organic compounds. Its molecular formula is C7H5BrFO. This chemical is primarily characterized by a bromine atom and a fluorine atom connected to the phenyl ring which is further attached to an alcohol group (-OH). The presence of these functional groups gives this compound unique chemical properties. This bromo-fluoro compound can be used in various scientific research and pharmaceutical applications, acts as an intermediate in synthetic chemistry to make more complex molecules. It hasn't well established toxicity but handling it usually requires standard safety precautions for chemicals.

InChI:InChI=1S/C7H6BrFO/c8-6-2-1-3-7(9)5(6)4-10/h1-3,10H,4H2

Upstream product

• 2252-37-1 2-bromo-6-fluorobenzoic acid 
• 360575-28-6 2-bromo-6-fluorobenzaldehyde 

Downstream Products

• 905710-71-6 2-bromo-6-fluoro-1-(methoxymethoxymethyl)benzene 
• 174671-88-6 1,3-Dihydro-4-fluoro-1-hydroxy-2,1-benzoxaborole 
• 1548-81-8 1-bromo-2-(bromomethyl)-3-fluorobenzene 
• 1182357-16-9 1-bromo-2-(chloromethyl)-3-fluorobenzene 
• 1198273-64-1 (2-bromo-6-fluorobenzyloxy)-tert-butyldimethylsilane 
• 1198273-71-0 6-[2-(tert-Butyldimethylsilanyloxymethyl)-3-fluorophenyl]-2-chloroimidazo[1,2-a]pyridine 
• 1198567-65-5 [2-(2-benzothiazol-2-ylimidazo[1,2-a]pyridin-6-yl)-6-fluorophenyl]methanol 
• 1198567-66-6 2-{6-[2-(tert-Butyldimethylsilanyloxymethyl)-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl}benzothiazole 
• 1198211-32-3 5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine 
• 1198568-59-0 {2-fluoro-6-[2-(1H-indol-5-yl)imidazo[1,2-a]pyridin-6-yl]phenyl}methanol 
• 1198568-96-5 C₂₈H₃₀FN₃OSi 
• 1198273-63-0 {2-Fluoro-6-[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}methanol 
• 1198273-68-5 {2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol 
• 1198273-70-9 2-(4-Chlorophenyl)-6-[3-fluoro-2-[(2-methoxyethyl)oxymethyl]phenyl]imidazo[1,2-a]pyridine 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE

The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha.

Synthesis of dihydroisobenzofurans via palladium-catalyzed sequential alkynylation/annulation of 2-bromobenzyl and 2-chlorobenzyl alcohols under microwave irradiation

The palladium-catalyzed synthesis of dihydroisobenzofurans has been performed by sequential Sonogashira cross-coupling/cyclization reactions between terminal alkynes and 2-(hydroxymethyl)bromoand chlorobenzenes in methanol as solvent at 130 °C under microwave irradiation. A 4,4'-dichlorobenzophenone oxime-derived chloro-bridged palladacycle is an efficient pre-catalyst to perform this tandem process using 2-dicyclohexylphosphanyl-2',4',6'-triisopropylbiphenyl (Xphos) as ancillary ligand and potassium hydroxide as base in the absence of a copper cocatalyst. Under these conditions, functionalized 2-bromo- and 2-chlorobenzaldehydes are also suitable partners in the domino process affording phthalans in good yields. All the reactions can be performed under air and employing reagentgrade chemicals under low loading conditions (1 mol% Pd).

POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF

Compounds of formula (I): wherein R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.