261724-74-7Relevant articles and documents
A new xantphos-type ligand and its gold(I) complexes: Synthesis, structure, luminescence
Besenyei, Gábor,Bitter, István,Párkányi, László,Szalontai, Gábor,Baranyai, Péter,Kunsági-Máté, éva,Faigl, Ferenc,Grün, Alajos,Kubinyi, Miklós
, p. 57 - 66 (2013/08/25)
A novel xantphos analog diphosphine ligand, 9,9-dimethyl-4,5- bis(diphenylphosphinomethyl)-9H-xanthene (X(CP)2), with methylene groups inserted between the xanthene skeleton and the two diphenylphosphine units, has been synthesized. A two-coordinate and a three-coordinate gold(I) complex of the ligand, [Au2Cl2(X(CP)2)] and [AuCl(X(CP)2)], have been prepared and studied by X-ray diffraction, NMR and optical spectroscopy. In the solid state, [AuCl(X(CP)2)] adopts a highly ordered structure with a planar xanthene skeleton that faces another plane composed of two phenyl rings and the AuCl moiety. The structure of [Au2Cl2(X(CP)2)] is much less regular, the two P-Au-Cl vectors point to the opposite sides of the folded xanthene backbone. The exchange-broadened resonances in the NMR spectra of [AuCl(X(CP) 2))] indicate that this complex exists as a mixture of various chemical species and/or conformers in solution. In contrast, the NMR spectra of [Au2Cl2(X(CP)2)] exclude any medium-range exchange processes. Aurophilic interactions are absent in both X(CP)2 complexes. X(CP)2, as well as its two gold complexes, is phosphorescent in the solid state; the complexes emit at higher wavelengths and with longer lifetimes than the free ligand.
Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani
Chibale, Kelly,Visser, Mark,Yardley, Vanessa,Croft, Simon L.,Fairlamb, Alan H.
, p. 1147 - 1150 (2007/10/03)
Derivatives of 9,9-dimethylxanthene was synthesised and evaluated against trypanothione reductase (TR) and in vitro against parasitic trypanosomes and leishmania. High in vitro antiparasitic activity was observed for some derivatives with one compound showing high activity against all three parasites (ED50 values of 0.02, 0.48 and 0.32 μM, for Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani, respectively). The lack of correlation between inhibitory activity against TR and ED50 values suggests that TR is not the target. (C) 2000 Elsevier Science Ltd. All rights reserved.
