261895-32-3

Basic information

• Product Name: phenylmethyl 5,6,11-trimethyl-1,2,3,4-tetrahydropyrido[4,3-b]carbazole-2-carboxylate
• Synonyms: phenylmethyl 5,6,11-trimethyl-1,2,3,4-tetrahydropyrido[4,3-b]carbazole-2-carboxylate
• CAS NO: 261895-32-3
• Molecular Weight: 398.505
• Mol File: 261895-32-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: phenylmethyl 5,6,11-trimethyl-1,2,3,4-tetrahydropyrido[4,3-b]carbazole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: phenylmethyl 5,6,11-trimethyl-1,2,3,4-tetrahydropyrido[4,3-b]carbazole-2-carboxylate(261895-32-3)
• EPA Substance Registry System: phenylmethyl 5,6,11-trimethyl-1,2,3,4-tetrahydropyrido[4,3-b]carbazole-2-carboxylate(261895-32-3)

Safety Data

• Hazardous Substances Data: 261895-32-3(Hazardous Substances Data)

Upstream product

• 261895-24-3 phenylmethyl 3-ethylidene-4-[(1-methylindol-2-yl)ethylidene]piperidine-1-carboxylate 
• 603-76-9 1-methylindole 

Downstream Products

• 18073-33-1 6-methylellipticine 

Relevant articles and documents

Concise Total Syntheses of Pyrido[4,3-b]carbazole Alkaloids Using Copper-Mediated 6π-Electrocyclization

Concise syntheses of 9-methoxyellipticine, 3,4-dihydroellipticine (μ-alkaloid D), 1,2,3,4-tetrahydroellipticine, 2-methyl-1,2,3,4-tetrahydroellipticine, olivacine, 3,4-dihydroolivacine, (±)-guatambuine, and (±)-janetine were developed starting from hexatriene intermediates readily obtained by Pd-catalyzed tandem cyclization/cross-coupling reaction of indolylborates. The route enables the facile construction of pyrido[4,3-b]carbazoles by Cu-catalyzed 6π-electrocyclization and subsequent transformation of the pyridocarbazole intermediates into pyrido[4,3-b]carbazole alkaloids. Concise total syntheses of pyrido[4,3-b]carbazole alkaloids were accomplished using Cu-catalyzed 6π-electrocyclization of hexatriene as a key step.

Palladium Catalysed Cross-Coupling Reaction with Indolylborate: A Concise Access to Ellipticine Derivatives

A novel approach to ellipticine derivatives is described. The palladium catalysed cross-coupling reaction of indolylborate 1 with vinylbromides 4 gives hexatrienes 5, which are subsequently converted to pyrido[4,3-b]carbazoles. In addition, the acid promoted spiroannelation reaction of hexatrienes 5 is observed to give spiroindoles 9.