2620-49-7

Basic information

• Product Name: 5-(azidomethyl)benzo[d][1,3]dioxole hydrochloride
• Synonyms: 5-(azidomethyl)benzo[d][1,3]dioxole hydrochloride
• CAS NO: 2620-49-7
• Molecular Formula: C₈H₉NO₂*ClH
• Molecular Weight: 213.62102
• Mol File: 2620-49-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(azidomethyl)benzo[d][1,3]dioxole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(azidomethyl)benzo[d][1,3]dioxole hydrochloride(2620-49-7)
• EPA Substance Registry System: 5-(azidomethyl)benzo[d][1,3]dioxole hydrochloride(2620-49-7)

Safety Data

• Hazardous Substances Data: 2620-49-7(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 2089-36-3 piperonal oxime 
• 4421-09-4 piperonylonitrile 
• 214783-17-2 5-(azidomethyl)benzo[d][1,3]dioxole 

Downstream Products

• 65609-28-1 1-(benzo[d][1,3]dioxol-5-ylmethyl)urea 
• 676435-25-9 N-benzo[1,3]dioxol-5-ylmethyl-4-chloro-2-hydroxy-benzamide 
• 226930-11-6 [1-(1,3-benzodioxol-5-ylmethyl)-1H-imidasol-5-yl]methanol 
• 67496-29-1 1-bromo-6-aminomethyl-3,4-(methylenedioxy)-benzene 

Relevant articles and documents

Bicyclic (alkyl)(amino)carbene (BICAAC) as a metal-free catalyst for reduction of nitriles to amines

Bicyclic (alkyl)(amino)carbene (BICAAC) is introduced as a metal-free catalyst for the reduction of various nitriles to the corresponding amine hydrochloride salts in the presence of pinacolborane. Mechanistic investigations combining experiments and DFT calculations suggest a B-H addition to the carbene center, which acts as a carrier of the hydride source. This journal is

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent and reducing agent. The process utilizes 1 mol% of the commercially available [Ru(p -cymene)Cl 2 ] 2, with a residence time of ca. 9 min, and a throughput of 50 mmol/h. The method was successfully applied to a range of aromatic nitriles providing the corresponding primary amines in good yields.