26210-75-3 Usage
Description
2-METHYL-5-BENZOFURANAMINE is a benzofuranamide analog that demonstrates potent inhibitory activity against Cryptosporidium parvum IMP dehydrogenase (CpIMPDH), a key enzyme involved in the growth and survival of the Cryptosporidium parvum parasite. 2-METHYL-5-BENZOFURANAMINE is characterized by its unique chemical structure, which allows it to effectively target and inhibit the enzyme, making it a promising candidate for the development of new therapeutic agents against cryptosporidiosis.
Uses
Used in Pharmaceutical Industry:
2-METHYL-5-BENZOFURANAMINE is used as a potential therapeutic agent for the treatment of cryptosporidiosis, a parasitic disease caused by the Cryptosporidium parvum parasite. Its low nanomolar inhibition of CpIMPDH makes it a promising candidate for the development of new drugs to combat this infection, particularly in cases where current treatments are ineffective or limited.
Used in Research Applications:
2-METHYL-5-BENZOFURANAMINE is also used as a research tool in the study of Cryptosporidium parvum IMP dehydrogenase and its role in the parasite's life cycle. By understanding the mechanism of action of this compound, researchers can gain valuable insights into the development of new strategies for targeting and inhibiting the enzyme, ultimately leading to the discovery of novel therapeutic agents for the treatment of cryptosporidiosis.
Check Digit Verification of cas no
The CAS Registry Mumber 26210-75-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,2,1 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 26210-75:
(7*2)+(6*6)+(5*2)+(4*1)+(3*0)+(2*7)+(1*5)=83
83 % 10 = 3
So 26210-75-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5H,10H2,1H3
26210-75-3Relevant articles and documents
Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis
Gallagher, Timothy,Glorius, Frank,Hu, Tianjiao,Moock, Daniel,Wagener, Tobias
supporting information, p. 13677 - 13681 (2021/05/10)
We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.
PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE
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Page/Page column 61, (2010/02/11)
There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected from -S(=O)(=O)- and -C(=O)-, and Y is -NR3-; or X is selected from -S(=O)(=O)- and -S-, and Y is -C(R4)(R5)-; L is an optional linker; and R3, R4 and R5 are each independently selected from H and hydrocarbyl; and wherein when R2 comprises the following structural moiety, Formula (II) wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1-C(=O)-NR3-L-R2; R1-S(=O)(=O)-C(R4)(R5)-L-R2; R1-S-C(R4)(R5)-L-R2; R1-NR3-S(=O)(=O)-L-R2; R1-NR3-C(=O)-L-R2; R1-C(R4)(R5)-S(=O)(=O)-L-R2; and R1-C(R4)(R5)-S-L-R2. These compounds are useful as 11β-hydroxysteriod dehydrogenase inhibitors in the treatment of i.a. diabetes.
