26216-55-7Relevant articles and documents
Conformationally restricted analogues of trimethoprim: 2,6-diamino-8- substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii
Gangjee, Aleem,Vasudevan, Anil,Queener, Sherry F.
, p. 3032 - 3039 (1997)
Twenty-two 2,6-diamino-8-substituted purines (2-23) were synthesized, in which rotation around the two flexible bonds of trimethoprim (TMP), linking the pyrimidine ring to the side chain phenyl ring, was restricted by incorporation into a purine ring, in
Purine Derivatives as Competitive Inhibitors of Human Erythrocyte Membrane Phosphatidylinositol 4-Kinase
Young, Rodney C.,Jones, Martin,Milliner, Kevin J.,Rana, Kishore K.,Ward, John G.
, p. 2073 - 2080 (2007/10/02)
The possibility of deriving a potent, cell-penetrating inhibitor of human erythrocyte PI 4-kinase, competitive with respect to ATP, has been investigated in a series of purine derivatives and analogues.The purine nucleus is not essential for binding to th
