262295-96-5Relevant articles and documents
Selective catalytic transfer hydrogenation of nitriles to primary amines using Pd/C
Vilches-Herrera, Marcelo,Werkmeister, Svenja,Junge, Kathrin,Boerner, Armin,Beller, Matthias
, p. 629 - 632 (2014/03/21)
The catalytic transfer hydrogenation of (hetero)aryl nitriles using ammonium formate has been investigated in detail. In the presence of commercially available Pd/C, a straightforward and selective reduction is achieved without any additives under mild conditions.
One-pot primary aminomethylation of aryl and heteroaryl halides with sodium phthalimidomethyltrifluoroborate
Murai, Norio,Miyano, Masayuki,Yonaga, Masahiro,Tanaka, Keigo
supporting information; experimental part, p. 2818 - 2821 (2012/07/17)
A one-pot primary aminomethylation of aryl halides, triflates, mesylates, and tosylates via Suzuki-Miyaura cross-coupling reactions with sodium phthalimidomethyltrifluoroborate followed by deamidation with ethylenediamine is reported.
A general and environmentally benign catalytic reduction of nitriles to primary amines
Enthaler, Stephan,Addis, Daniele,Junge, Kathrin,Erre, Giulia,Beller, Matthias
experimental part, p. 9491 - 9494 (2009/10/14)
An easily accessible in situ catalyst composed of [Ru(cod)methylallyl 2] and DPPF was developed for the environmentally benign hydrogenation of various nitriles to give primary amines. A solution of benzonitrile in toluene was transferred by syringe into an autoclave that contained argon and KOtBu. The catalyst was generated in situ by stirring [Ru(cod)methylallyl2] and DPPF in toluene for 10 min and transferring the solution by syringe into the autoclave. the reaction mixture was filtered through a short plug of silica gel and the yield was measured by GC. A superior catalyst activity with a TOF of up to 5783 h-1 is achieved in the model reaction under optimized conditions. The results also show that [Ru(cod)methylallyl2]/DPPF catalyst system exhibit a broad functional group tolerance.
