262366-32-5 Usage
Description
(Z)-N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-(((2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)acetamide is a complex organic compound with a unique molecular structure. It is characterized by the presence of an indolin-3-ylidene moiety, a phenyl group, and a methylpiperazinyl group, all of which contribute to its chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(Z)-N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-(((2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)acetamide is used as a potent inhibitor of MELK, a serine/threonine protein kinase involved in cell cycle regulation and proliferation. It is particularly effective in inhibiting the expression of the anti-apoptotic protein Mcl-1 and suppressing the growth of triple-negative breast cancer (TNBC) cells.
Additionally, (Z)-N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-(((2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)acetamide is an impurity of Intedanib (I666650), an antitumor agent. Its presence in Intedanib may contribute to the overall therapeutic effects of the drug, although further research is needed to fully understand its role and potential applications in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 262366-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,2,3,6 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 262366-32:
(8*2)+(7*6)+(6*2)+(5*3)+(4*6)+(3*6)+(2*3)+(1*2)=135
135 % 10 = 5
So 262366-32-5 is a valid CAS Registry Number.
262366-32-5Relevant articles and documents
INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE
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Page/Page column 66, (2018/09/20)
The present disclosure relates to indolinone compounds, compositions, and methods for the inhibition of maternal embryonic leucine zipper kinase (MELK). The present disclosure further relates to indolinone compounds, compositions, and methods for the treatment or prevention of a cancer (for example, triple negative breast cancer).
