262433-02-3

Basic information

• Product Name: 4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER
• Synonyms: tert-Butyl (2-Methoxy-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbaMate;4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER
• CAS NO: 262433-02-3
• Molecular Formula: C₁₈H₂₈BNO₅
• Molecular Weight: 349.23
• Product Categories: Heterocyclic Compounds
• Mol File: 262433-02-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 416.7°Cat760mmHg
• Flash Point: 205.8°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.504
• PKA: 13.37±0.70(Predicted)
• CAS DataBase Reference: 4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER(262433-02-3)
• EPA Substance Registry System: 4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER(262433-02-3)

Safety Data

• Hazardous Substances Data: 262433-02-3(Hazardous Substances Data)

Usage

General Description

4-(Tert-butoxycarbonylamino)-3-methoxyphenylboronic Acid, Pinacol Ester, is a chemical compound typically utilized in various chemical reactions, due to the boronic acid group. The compound itself exists as a solid, pinacol ester derivative of a boronic acid. Its structure is distinctive because it has both an amino group, which has been protected by a tert-butoxycarbonyl group, and a methoxy group on the phenyl ring. This makes it highly versatile in diverse chemical syntheses. 4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER's applications range from medicinal chemistry, where it can be used as a pharmaceutical intermediate, to material science, as well as in coupling reactions such as Suzuki-Miyaura cross-coupling reactions.

InChI:InChI=1/C18H28BNO5/c1-16(2,3)23-15(21)20-13-10-9-12(11-14(13)22-8)19-24-17(4,5)18(6,7)25-19/h9-11H,1-8H3,(H,20,21)

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 262433-01-2 (4-bromo-2-methoxyphenyl)carbamic acid tert-butyl ester 
• 461699-81-0 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 59557-91-4 4-bromo-2-methoxyaniline 

Downstream Products

• 330793-47-0 (4-{4-amino-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 832696-35-2 N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-methyl-1H-indole-3-carboxamide 
• 330794-21-3 benzyl 4-(4-amino-3-{4-[(tert-butoxycarbonyl)amino]-3-methoxyphenyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-piperidinecarboxylate 
• 1124330-11-5 benzyl 4-[3-methoxy-4-[(2-methylpropan-2-yl)oxycarbonyl-amino]phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate 
• 1224708-53-5 tert-butyl N-[2-methoxy-4-(2-pyridyl)phenyl]carbamate 
• 1224708-46-6 tert-butyl 4-(4-(tert-butoxycarbonylamino)-3-methoxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1224708-50-2 tert-butyl 4-(4-(tert-butoxycarbonylamino)-3-methoxyphenyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 262444-50-8 4-(4-amino-5-(4-amino-3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanone 

Relevant articles and documents

Tyrosine Kinase Inhibitor And Uses Thereof

Disclosed is a compound of Formula (I) or a pharmaceutically acceptable salt, ester, or solvate thereof, or their stereoisomers, which can be used as tyrosine kinase inhibitor. Also disclosed is a method for preparing the compound, a pharmaceutical composition and a kit comprising the compound, and uses of the compound. The compound can be used as tyrosine kinase inhibitor, or can be used to reduce or inhibit activity of EGFR or mutant thereof, such as EGFR mutant comprising T790M mutation, in a cell, or to treat and/or prevent a disease associated with overactivity of EGFR, such as cancer.

Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof

The invention relates to a method for preparation of aminoaryl- or aminoheteroarylboronic acids and esters and salts thereof in which an optionally substituted aminoaryl or aminoheteroaryl compound is protected at its nitrogen site via condensation with a carbonyl compound, subsequently metalated and converted with a suitable boron compound. Depending on the subsequent work-up and removal of the protective group, the corresponding boronic acid, the anhydride or the boronic acid ester thereof is obtained

Thienopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.