26259-77-8

Basic information

• Product Name: Cholest-5-ene-3beta,26-diol
• Synonyms: Cholest-5-ene-3beta,26-diol
• CAS NO: 26259-77-8
• Molecular Formula: C27H46O2
• Molecular Weight: 402.65
• Mol File: 26259-77-8.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 517.1 °C at 760 mmHg
• Flash Point: 215.6 °C
• Appearance: /
• Density: 1.03 g/cm³
• CAS DataBase Reference: Cholest-5-ene-3beta,26-diol(CAS DataBase Reference)
• NIST Chemistry Reference: Cholest-5-ene-3beta,26-diol(26259-77-8)
• EPA Substance Registry System: Cholest-5-ene-3beta,26-diol(26259-77-8)

Safety Data

• Hazardous Substances Data: 26259-77-8(Hazardous Substances Data)

Upstream product

• 468-99-5 kryptogenin 
• 77611-30-4 (25R)-26-hydroxy-16-oxocholesterol 
• 43204-21-3 (20R,25R)-cholest-5-ene-3β,26-diol 3,26-diacetate 
• 101978-09-0 (2R,6R)-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptan-1-ol 
• 79045-93-5 3β,26-dibezoyloxycholest-5-ene-16β-ol mesylate 
• 71472-90-7 (25R)-3β.26-Dibenzoyloxy-5-cholesten-16-on 
• 13095-61-9 26-hydroxycholesterol 
• 7554-95-2 kryptogenin diacetate 
• 869858-31-1 (25R)-cholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether 
• 894357-63-2 (25R)-cholest-5-ene-3β,16β,26-triol 3β,26-dipivalate 
• 31327-56-7 (25R)-cholest-5-ene-3β,16β,26-triol 
• 869858-16-2 23-iodo-24-norchol-5-en-3β-ol 
• 869858-15-1 24-norchol-5-en-3β-23-diol 23-tosylate 
• 869858-29-7 (25S)-24-phenylsulfonylcholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether 

Downstream Products

• 113917-70-7 C₄₇H₆₀F₆O₆ 
• 113917-68-3 C₄₇H₆₀F₆O₆ 
• 113917-68-3 C₄₇H₆₀F₆O₆ 
• 105078-98-6 (25S)-3β-acetoxy-26-trityloxycholest-5-ene 
• 56792-57-5 (3S,8S,9S,10R,13R,14S,17R)-17-((1R,5R)-1,5-Dimethyl-6-trityloxy-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 
• 19257-21-7 (25ξ)-26-hydroxycholest-4-en-3-one 
• 71472-91-8 (25R)-5-Cholesten-3β,26-diol-26-tosylat 
• 13095-61-9 (25R)-cholest-5-ene-3β,26-diol 
• 192187-67-0 (25R)-7α,26-dihydroxycholest-4-en-3-one 
• 148988-28-7 3β,27-dihydoxycholest-5-en-7-one 
• 949004-12-0 (25S)-3-keto-5α-cholest-7-en-26-oic acid 

Relevant articles and documents

Synthesis of (25R)-26-hydroxycholesterol.

We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction.

PEPTIDES

The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Stereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from corals

A stereoselective synthesis of (25S)-Δ1-, (25S)-Δ1,4-, (25S)-Δ1,7-, (25S)- Δ8(14)-, (25S)-Δ4,6,8(14)-dafachronic acid, methyl (25S)-Δ1,4-dafachronate and (25S)-5α-hydroxy-3,6- dioxocholest-7-en-26-oic acid is described. (25S)-Δ1,4- Dafachronic acid and its methyl ester are natural products isolated from corals and have been obtained by synthesis for the first time. (25S)-5α-Hydroxy- 3,6-dioxocholest-7-en-26-oic acid represents a promising synthetic precursor for cytotoxic marine steroids.