262593-63-5

Basic information

• Product Name: 1H-INDOLE, 5-(TRIFLUOROMETHOXY)-
• Synonyms: 1H-INDOLE, 5-(TRIFLUOROMETHOXY)-;5-(TRIFLUOROMETHOXY)INDOLE;5-(Trifluoromethoxy)
• CAS NO: 262593-63-5
• Molecular Formula: C9H6F3NO
• Molecular Weight: 201.15
• Mol File: 262593-63-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 247.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.413±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 16.06±0.30(Predicted)
• CAS DataBase Reference: 1H-INDOLE, 5-(TRIFLUOROMETHOXY)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE, 5-(TRIFLUOROMETHOXY)-(262593-63-5)
• EPA Substance Registry System: 1H-INDOLE, 5-(TRIFLUOROMETHOXY)-(262593-63-5)

Safety Data

• Hazardous Substances Data: 262593-63-5(Hazardous Substances Data)

Usage

General Description

1H-Indole, 5-(trifluoromethoxy)- is a chemical compound with the molecular formula C9H6F3NO. It is a derivative of the indole structure, which is a heterocyclic aromatic compound commonly found in many natural products and pharmaceuticals. The addition of a trifluoromethoxy group to the 5-position of the indole ring gives this compound unique properties and potential applications. It may be used as a building block in organic synthesis, as a pharmaceutical intermediate, or as a research tool in the study of indole-containing compounds. The trifluoromethoxy group also imparts increased lipophilicity and stability to the molecule, making it a valuable component in drug discovery and development. Overall, 1H-Indole, 5-(trifluoromethoxy)- is a versatile and important chemical with various potential uses in the fields of chemistry, pharmacology, and materials science.

Upstream product

• 169037-23-4 5-trifluoromethoxy-1H-indole-2,3-dione 

Relevant articles and documents

N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR

The present invention relates to the use compounds of formula I which are antagonists of the 5-HT 6 receptor, for treating a cognitive disorder selected from the group consisting of age-related cognitive decline, mild cognitive impairment and dementia

Piperidine-indole compounds having 5-HT6 affinity

Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula: wherein: R1 is selected from the group consisting of H and C1-4alkyl; R2 is selected from the group consisting of H, C1-4alkyl and benzyl; - - - represents a single or double bond; R3 is selected from the group consisting of COR5 and SO2R5; R4a is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4b is selected from the group consisting of H, hydroxy, halo, C3-7cycloalkyloxy, C1-4alkoxy, C1-4alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R4c is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4d is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; and R5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C1-4alkoxy, C1-4alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C1-4alkylcarbonyl, C1-4alkoxycarbonyl and C1-4alkylS-. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.