262601-04-7

Basic information

• Product Name: {[2-(4-hydroxy-phenyl)-vinylcarbamoyl]-methyl}-carbamic acid tert-butyl ester
• Synonyms: {[2-(4-hydroxy-phenyl)-vinylcarbamoyl]-methyl}-carbamic acid tert-butyl ester
• CAS NO: 262601-04-7
• Molecular Weight: 292.335
• Mol File: 262601-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {[2-(4-hydroxy-phenyl)-vinylcarbamoyl]-methyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {[2-(4-hydroxy-phenyl)-vinylcarbamoyl]-methyl}-carbamic acid tert-butyl ester(262601-04-7)
• EPA Substance Registry System: {[2-(4-hydroxy-phenyl)-vinylcarbamoyl]-methyl}-carbamic acid tert-butyl ester(262601-04-7)

Safety Data

• Hazardous Substances Data: 262601-04-7(Hazardous Substances Data)

Upstream product

• 770-05-8 octopamine hydrochloride 
• 4530-20-5 BOC-glycine 
• 262601-03-6 N-[2-(4-acetoxyphenyl)acetoxyethyl](Boc)glycinamide 

Downstream Products

• 262601-09-2 (E)-5-[[bis[[(1,1-dimethoxy)carbonyl]amino]methylene]amino]-2-oxopentanoyl-N-[2-(4-acetoxyphenyl)ethenyl]glycinamide 
• 262601-08-1 (E)-5-[[bis[[(1,1-dimethoxy)carbonyl]amino]methylene]amino]-2-hydroxypentanoyl-N-[2-(4-acetoxyphenyl)ethenyl]glycinamide 
• 262601-12-7 (E)-L-[N-Boc-α-glutamyl]-N-[2-(4-hydroxyphenyl)ethenyl]glycinate tert-butyl ester 
• 262601-06-9 (E)-N-[2-(4-acetoxyphenyl)ethenyl]glycinamide 
• 262601-13-8 (E)-N-[2-(4-hydroxyphenyl)ethenyl]glycinamide 
• 262601-05-8 (E)-N-[2-(4-acetoxyphenyl)ethenyl](Boc)glycinamide 

Relevant articles and documents

Total Syntheses of (±)-Anchinopeptolide D and (±)-Cycloanchinopeptolide D

The first synthesis of (±)-anchinopeptolide D (4) has been accomplished in seven steps in 10% overall yield from octopamine hydrochloride (17), N-(Boc)glycine (16), and 5-amino-2-hydroxypentanoic acid (22). The key step is the aldol dimerization and hemiaminal formation of α-keto amide 26, which gives primarily protected anchinopeptolide D 27 under kinetically controlled conditions. Cycloanchinopeptolide D (31) has been prepared by the unprecedented head-to-head photodimerization of the two hydroxystyrylamides of 4 using the hydrophobic effect in water to force the two side chains into close proximity so that [2 + 2] cycloaddition is faster than trans to cis double bond isomerization. Coupling of amine 21 with pyroglutamic acid affords the naturally occurring tripeptide 35, which had been assigned glutamic acid structure 34.