262616-20-6

Basic information

• Product Name: 7-(4-methoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester
• Synonyms: 7-(4-methoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester
• CAS NO: 262616-20-6
• Molecular Weight: 397.471
• Mol File: 262616-20-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(4-methoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-methoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester(262616-20-6)
• EPA Substance Registry System: 7-(4-methoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester(262616-20-6)

Safety Data

• Hazardous Substances Data: 262616-20-6(Hazardous Substances Data)

Upstream product

• 262616-16-0 methyl (S)-2-tert-butoxycarbonyl-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 142335-42-0 (3S)-2-(tert-butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 
• 128502-56-7 (3S)-1,2,3,4-tetrahydro-7-hydroxy-isoquinoline-3-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 262616-17-1 methyl (S)-2-tert-butoxycarbonyl-7-trifluoromethanesulfonyloxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 

Relevant articles and documents

Novel Dmt-Tic dipeptide analogues as selective delta-opioid receptor antagonists

A series of Dmt-Tic analogues with substitution on the Tic aromatic ring has been synthesized and evaluated for opioid receptor affinity and activation. Incorporation of large hydrophobic groups at position 7 of Tic did not greatly alter the δ opioid receptor binding affinities of the dipeptides whereas substitution at position 6 substantially diminished their affinity. These modified Dmt-Tic peptides showed binding affinities as low as 2.5 nM with up to 500-fold selectivity for the δ versus μ opioid receptor and proved to be δ receptor antagonists.