262863-78-5Relevant articles and documents
Dehydrophenylalanine derivatives as VLA-4 integrin antagonists
Porter, John R.,Archibald, Sarah C.,Brown, Julien A.,Childs, Kirstie,Critchley, David,Head, John C.,Parton, Ted A. H.,Robinson, Martyn K.,Shock, Anthony,Taylor, Richard J.,Warrellow, Graham J.
, p. 805 - 808 (2007/10/03)
We describe a series of dehydrophenylalanine derivatives where the Z isomers are potent VLA-4 antagonists but are subject to rapid biliary clearance and the E isomers have poor activity but have a slower rate of clearance. These configurationally constrained molecules have led to the design of a novel class of benzodiazepine VLA-4 antagonists.
