263149-10-6

Basic information

• Product Name: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE
• Synonyms: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE;4-Chloro-3-cyano-7-hydroxy-6-methoxyquinoline;4-Chloro-7-hydroxy-6-methoxy-3-quinolinecarbonitrile;3-Quinolinecarbonitrile, 4-chloro-7-hydroxy-6-Methoxy-
• CAS NO: 263149-10-6
• Molecular Formula: C₁₁H₇ClN₂O₂
• Molecular Weight: 234.63848
• EINECS: 1592732-453-0
• Mol File: 263149-10-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 438.954 °C at 760 mmHg
• Flash Point: 219.272 °C
• Appearance: /
• Density: 1.48
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 7.41±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE(263149-10-6)
• EPA Substance Registry System: 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE(263149-10-6)

Safety Data

• Hazardous Substances Data: 263149-10-6(Hazardous Substances Data)

Usage

Description

4-Chloro-7-hydroxy-6-methoxy-quinoline-3-carbonitrile is a synthetic compound characterized by its quinoline core, featuring a chloro, hydroxy, and methoxy group at the 4th, 7th, and 6th positions, respectively. It also contains a nitrile group at the 3rd position, which contributes to its unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
4-Chloro-7-hydroxy-6-methoxy-quinoline-3-carbonitrile is used as a key intermediate in the synthesis of Src inhibitors for the development of drugs targeting various diseases. Src inhibitors are of interest due to their potential role in treating conditions such as cancer, where they can help regulate cell growth and division, as well as other cellular processes.
Used in Chemical Research:
4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE is also utilized in chemical research for the exploration of novel quinoline-based structures and their potential applications. The presence of functional groups in 4-chloro-7-hydroxy-6-methoxy-quinoline-3-carbonitrile allows for further chemical modifications and the development of new derivatives with improved properties and therapeutic effects.

InChI:InChI=1/C11H7ClN2O2/c1-16-10-2-7-8(3-9(10)15)14-5-6(4-13)11(7)12/h2-3,5,15H,1H3

Upstream product

• 741276-43-7 7-isopropyloxy-6-methoxy-4-chloroquinoline-3-carbonitrile 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 3535-27-1 methyl 4-isopropoxy-3-methoxybenzoate 
• 50413-53-1 methyl 2-amino-4-isopropoxy-5-methoxybenzoate 
• 948553-02-4 4-isopropoxy-5-methoxy-2-nitro-benzoic acid methyl ester 
• 319492-96-1 7-isopropyloxy-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile 
• 214476-99-0 7-benzyloxy-4-chloro-6-methoxyquinoline-3-carbonitrile 

Downstream Products

• 214470-68-5 7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile 
• 380844-38-2 4-chloro-7-(4-chlorobutoxy)-6-methoxy-3-quinolinecarbonitrile 
• 380844-40-6 4-chloro-7-(5-chloropentoxy)-6-methoxy-3-quinolinecarbonitrile 
• 214470-72-1 4-chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile 
• 423180-28-3 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile 
• 622369-44-2 4-chloro-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile 
• 214487-30-6 (4-chloro-6-methoxy-7-[3-(1-morpholino)propoxy]-3-quinolinecarbonitrile) 
• 492444-39-0 7-[3-(4-methylpiperazin-1-yl)propoxy]-6-methoxy-4-chloro-quinoline-3-carbonitrile 
• 214470-55-0 4-chloro-6,7-dimethoxyquinoline-3-carbonitrile 
• 622368-88-1 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]-3-quinolinecarbonitrile 
• 622369-21-5 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-methylpiperidin-4-yl)propoxy]quinoline-3-carbonitrile 
• 380844-42-8 7-(2-chloroethoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 
• 380844-44-0 7-(4-chlorobutoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 

Relevant articles and documents

Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors

This invention provides compounds of formula 1 wherein R1, G1, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

Derivatives of quinoline as inhibitors for MEK

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof. wherein: n is 0-1; X and Y are independently selected from -NH-, -O-, -S-, or -NR8- where R8 is alkyl of 1-6 carbon atoms and X may additionally comprise a CH2 group; R7 is a group (CH2)mR9 where m is 0,or an integer of from 1-3 and R9 is a substituted aryl group, an optionally substituted cycloalkyl ring of up to 10 carbon atoms, or an optionally substituted heterocyclic ring or an N-oxide of any nitrogen containing ring; R6 is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a divalent pyridinyl, pyimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified groups; R1, R2, R3 and R4 are each independently selected from hydrogen or various specified organic groups. Compounds are useful as pharmaceuticals for the inhibition of MEK activity.

Substituted 3-cyanoquinolines

This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.