263328-20-7Relevant articles and documents
Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: Lead identification and SAR of 3- and 4-substituted derivatives
Genin, Michael J.,Biles, Carolyn,Keiser, Barb J.,Poppe, Susan M.,Swaney, Steven M.,Tarpley, W. Gary,Yagi, Yoshihiko,Romero, Donna L.
, p. 1034 - 1040 (2007/10/03)
Through computationally directed broad screening, a novel 1,5- diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been discovered. Compound 2 (PNU-32945) was found to have good activity versus wild-type (ICs