263698-97-1 Usage
Description
2-Chloro-6-(triMethylsilyl)pyridine is a chemical compound with the molecular formula C8H11ClNSi. It is a derivative of pyridine, with a chloro and trimethylsilyl group substituting at the 2 and 6 positions, respectively. This colorless to pale yellow liquid is air and moisture sensitive, requiring careful handling in a well-ventilated area.
Uses
Used in Organic Synthesis:
2-Chloro-6-(triMethylsilyl)pyridine is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions and transformations.
Used as a Protecting Group:
In the synthesis of complex organic molecules, 2-chloro-6-(triMethylsilyl)pyridine serves as a protecting group for alcohols and amines, preventing unwanted side reactions and ensuring the desired product is obtained.
Used in Pharmaceutical Production:
2-chloro-6-(triMethylsilyl)pyridine is utilized in the production of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Production:
2-Chloro-6-(triMethylsilyl)pyridine is also employed in the creation of agrochemicals, which are essential for agriculture to protect crops and enhance yields.
Check Digit Verification of cas no
The CAS Registry Mumber 263698-97-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,3,6,9 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 263698-97:
(8*2)+(7*6)+(6*3)+(5*6)+(4*9)+(3*8)+(2*9)+(1*7)=191
191 % 10 = 1
So 263698-97-1 is a valid CAS Registry Number.
263698-97-1Relevant articles and documents
Lithiation of 2-heterosubstituted pyridines with BuLi-LiDMAE: Evidence for regiospecificity at C-6
Gros, Philippe,Choppin, Sabine,Mathieu, Julien,Fort, Yves
, p. 234 - 237 (2002)
The determination of the initial deprotonation site of 2-chloro- and 2-methoxypyridine during reaction with BuLi-LiDMAE has been investigated. A series of experiments on deuterated regioisomers revealed a direct lithiation at C-6 excluding a potential first classical ortholithiation and lithium equilibration in the reaction medium. These results suggested that the formation of lithium aggregates at the neighboring of the pyridinic nitrogen atom favored BuLi delivery at C-6 as well as 6-lithio intermediate stabilization.
Unusual C-6 lithiation of 2-chloropyridine-mediated by BuLi-Me2N(CH2)2OLi. New access to 6-functional-2-chloropyridines and chloro-bis-heterocycles
Choppin, Sabine,Gros, Philippe,Fort, Yves
, p. 803 - 805 (2007/10/03)
Formula Presented The reaction of 2-chloropyridine with alkylithium generally results in nucleophilic addition leading to the loss of chlorine atom while exclusive directed ortho metalation is obtained using LDA. Herein it is shown that the BuLi-Me2
