263745-37-5Relevant articles and documents
BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS
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Page/Page column 717; 718, (2018/03/25)
Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.
Isoindole-imide compounds and compositions comprising and methods of using the same
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Page/Page column 76-77, (2010/11/26)
This invention relates to isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
Structure-activity relationship and rational design of 3,4-dephostatin derivatives as protein tyrosine phosphatase inhibitors
Watanabe, Takumi,Suzuki, Takayuki,Umezawa, Yoji,Takeuchi, Tomio,Otsuka, Masami,Umezawa, Kazuo
, p. 741 - 752 (2007/10/03)
Several alkyl- and O-methylated-3,4-dephostatin were synthesized and evaluated for their inhibitory activity toward protein tyrosine phosphatase. Alkyl chains with a length up to that of the pentyl group gave tolerable inhibition, whereas methylation of h