26409-32-5

Basic information

• Product Name: 3,5-bis(4-methylphenyl)pyridine
• Synonyms: 3,5-bis(4-methylphenyl)pyridine
• CAS NO: 26409-32-5
• Molecular Weight: 259.351
• Mol File: 26409-32-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 3,5-bis(4-methylphenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(4-methylphenyl)pyridine(26409-32-5)
• EPA Substance Registry System: 3,5-bis(4-methylphenyl)pyridine(26409-32-5)

Safety Data

• Hazardous Substances Data: 26409-32-5(Hazardous Substances Data)

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 2039-87-4 2-chlorostyrene 
• 68-12-2 N,N-dimethyl-formamide 
• 1073-67-2 4-vinylbenzyl chloride 
• 100-42-5 styrene 
• 55-21-0 benzamide 
• 766-97-2 4-n-methylphenylacetylene 
• 625-92-3 3,5-dibromopyridine 
• 5142-75-6 tri(p-tolyl)bismuth 
• 5720-05-8 4-methylphenylboronic acid 
• 2457-47-8 3,5-dichloropyridine 
• 195062-57-8 p-tolylboronic pinacol ester 
• 106-38-7 para-bromotoluene 
• 7089-26-1 1,1,5,5-tetramethyl-3-(p-tolyl)-1,5-diazapentadienium perchlorate 

Relevant articles and documents

Base-promoted one-pot synthesis of pyridine derivatives via aromatic alkyne annulation using benzamides as nitrogen source

In the presence of Cs2CO3, the first simple, efficient, and one-pot procedure for the synthesis of 3,5-diaryl pyridines via a variety of aromatic terminal alkynes with benzamides as the nitrogen source in sulfolane is described. The formation of pyridine derivatives accompanies the outcome of 1,3-diaryl propenes, which are also useful intermediates in organic synthesis. Thus, pyridine ring results from a formal [2+2+1+1] cyclocondensation of three alkynes with benzamides, and one of the alkynes provides one carbon, whilst benzamides provide a nitrogen source only. A new transformation of alkynes as well as new utility of benzamide are found in this work.

Method for constructing 3,5-disubstituted pyridine by utilizing mixed styrene derivative and N,N-dimethylformamide

The invention discloses a method for constructing 3,5-disubstituted pyridine by utilizing mixed styrene derivative and N,N-dimethylformamide. The method comprises the following step: subjecting the mixed styrene derivative, N,N-dimethylformamide and peroxydisulfate to a cyclization reaction under the catalytic action of iodized salt so as to obtain symmetrical and asymmetrical mixed 3,5-disubstituted pyridine products at the same time. According to the method, 3,5-disubstituted pyridine is synthesized from the mixed styrene derivative and DMF through one-step oxidative cyclization under the catalysis of iodate; and the method has the advantages of low raw material and catalyst cost, mild reaction conditions, capability of realizing high-yield preparation of the symmetrical and asymmetrical3,5-disubstituted pyridine products at the same time and the like.

Insight into Copper Catalysis: In Situ Formed Nano Cu2O in Suzuki-Miyaura Cross-Coupling of Aryl/Indolyl Boronates

A ligand-free copper catalyzed Suzuki-Miyaura coupling of 3,5-diiodopyridine with aryl and indole boronates has been explored in good to excellent yields. In situ generation of nano-Cu2O from CuCl2 under the reaction conditions has been discovered for the first time. The generality of the reaction was further demonstrated by the arylation of 5-iodopyrimidine, iodopyridines, iodobenzenes, and diiodobenzenes and resulted in good to moderate yields. Moreover, bisindole alkaloid Scalaridine A has been successfully synthesized in 60% overall yield.