26413-58-1

Basic information

• Product Name: 2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE
• Synonyms: 2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE;BUTTPARK 43\57-37;2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHL;2-CHLORO-6-METHYLPYRIDINE-4- CARBONYL CHLORIDE 95%;2-Chloro-6-methylisonicotinoyl chloride;2-Chloro-6-methylpyridine-4-carbonyl chloride ,97%
• CAS NO: 26413-58-1
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.03
• Product Categories: Carbonyl Chlorides;Pyridines
• Mol File: 26413-58-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 118 °C
• Flash Point: 110 °C
• Appearance: /
• Density: 1.361 g/mL at 25 °C
• Vapor Pressure: 0.00688mmHg at 25°C
• Refractive Index: n20/D 1.5555
• PKA: -0.88±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE(26413-58-1)
• EPA Substance Registry System: 2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE(26413-58-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• WGK Germany: 3
• Hazardous Substances Data: 26413-58-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C7H5Cl2NO/c1-4-2-5(7(9)11)3-6(8)10-4/h2-3H,1H3

Upstream product

• 25462-85-5 2-chloro-6-methylpyridine-4-carboxylic acid 
• 86454-13-9 1,2-dihydro-6-methyl-2-oxo-4-pyridinecarboxylic acid 

Downstream Products

• 25462-95-7 2-Chlor-6-methyl-isonicotinsaeureamid 
• 896739-39-2 2-chloro-N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-6-methylpyridin-4-carboxamide 
• 1032749-55-5 (2-chloro-6-methylpyridin-4-yl)(4-hydroxy-3,5-dimethylphenyl)methanone 
• 1145355-10-7 1-(2-chloro-6-methyl-pyridine-4-carbonyl)-3-(3,4-difluoro-phenyl)-thiourea 
• 1145355-23-2 1-(2-chloro-6-methyl-pyridine-4-carbonyl)-3-(3-methoxy-5-trifluoromethyl-phenyl)-thiourea 
• 1145355-37-8 1-(2-chloro-6-methyl-pyridine-4-carbonyl)-3-(3-fluoro-5-methoxy-phenyl)-thiourea 
• 3998-90-1 2-chloro-6-methyl-isonicotinic acid methyl ester 
• 1166208-77-0 isosorbide-2-aspirinate-5-(2-chloro-6-methylpyridine-4-oate) 
• 1333167-33-1 5-(4-phenoxyphenyl)-5-(4-(2-chloro-6-methylpyridine-4-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1421707-26-7 (2-chloro-6-methyl-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone 
• 1112177-31-7 rac-N-(3-methoxybenzyl)-6-methyl-4-(2-((tetrahydro-2H-pyran-3-yl)methyl)-2H-tetrazol-5-yl)picolinamide 
• 1112174-74-9 N-(3-methoxybenzyl)-4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinamide 
• 1112174-98-7 N-(3-methoxybenzyl)-4-(2-(((cis)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinamide 
• 1112175-07-1 N-(3-methoxybenzyl)-4-(2-(((trans)-4-hydroxycyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinamide 

Relevant articles and documents

HETEROCYCLIC AZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES

The invention relates to heterocyclic compounds of formula (I) and (IV) or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

NOVEL SPIROINDOLINE COMPOUNDS

This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

6,6′-Dimethyl-2,2′-bipyridine-4-ester: A pivotal synthon for building tethered bipyridine ligands

We describe an efficient and scalable synthesis of 4-carbomethoxy-6,6′-dimethyl-2,2′-bipyridine starting from easily available substituted 2-halopyridines and based on the application of modified Negishi cross-coupling conditions. This compound is a versatile starting material for the synthesis of 4-functionalized 2,2′-bipyridines bearing halide, alcohol, amine, and other functionalities, suitable for conjugation to biological material (2a-c, 3a-g). The utility of this compound in the construction of more complex architectures was further demonstrated by the synthesis of two bifunctional lanthanide chelators; an open chain ligand based on one 2,2′-bipyridine unit and a cryptand based on three 2,2′-bipyridine units [N2(bpy)3COOMe]. In the field of luminophoric biolabels, the photophysical properties of the corresponding Eu(III) cryptate are reported.