264208-60-8Relevant articles and documents
Implant he loni intermediate compound and its preparation method
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Paragraph 0010; 0093-0098, (2017/10/23)
The invention discloses a vandetanib intermediate compound and a preparation method thereof. The preparation method of the above compound I is characterized in that a compound V is reduced in an organic solvent under the action of boron hydride and iodine. The preparation method has the advantages of mild reaction condition, simple operation, low cost, and suitableness for industrial production.
Quinazoline derivatives
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Page column 45, (2010/02/08)
The invention concerns quinazoline derivatives of Formula (I) wherein Q1includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1includes a direct bond and O and Q3includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2and R3is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of T cell mediated diseases or medical conditions in a warm-blooded animal.