2645-02-5

Basic information

• Product Name: Methyl 2-(4-methylphenylsulfonamido)acetate
• Synonyms: methyl 2-(4-methylphenylsulfonamido)acetate;Methyl 2-[(4-Methylbenzene)sulfonaMido]acetate;Methyl N-[(4-methylphenyl)sulphonyl]glycinate, N-Tosylglycine methyl ester, Methyl [(4-methylphenyl)sulphonamido]acetate;N-(Toluene-4-sulphonyl)glycine methyl ester;methyl 2-[(4-methylphenyl)sulfonylamino]acetate;methyltosylglycinate;T0514-7020;TsNHCH2COOCH3
• CAS NO: 2645-02-5
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.28
• Mol File: 2645-02-5.mol
• Article Data: 29

Chemical Properties

• Melting Point: 89-91°C
• Boiling Point: 372.5 °C at 760 mmHg
• Flash Point: 179.1 °C
• Appearance: /
• Density: 1.261
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.09±0.50(Predicted)
• CAS DataBase Reference: Methyl 2-(4-methylphenylsulfonamido)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-methylphenylsulfonamido)acetate(2645-02-5)
• EPA Substance Registry System: Methyl 2-(4-methylphenylsulfonamido)acetate(2645-02-5)

Safety Data

• Hazardous Substances Data: 2645-02-5(Hazardous Substances Data)

Usage

General Description

Methyl 2-(4-methylphenylsulfonamido)acetate is a chemical compound with a molecular formula C11H15NO4S. It is a sulfonamide derivative that contains a sulfonamido group attached to a methyl acetate group. Methyl 2-(4-methylphenylsulfonamido)acetate is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its potential as a building block for biologically active compounds. It is also used as a reagent in organic chemistry reactions, particularly in the formation of amide and ester compounds. Methyl 2-(4-methylphenylsulfonamido)acetate is a white crystalline solid that is soluble in organic solvents and has a relatively high melting point. Its properties and reactivity make it a valuable tool in the development and production of various chemical products.

Upstream product

• 67-56-1 methanol 
• 1080-44-0 N-Tosylglycine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 50487-71-3 4-methyl-N-(2-propenyl)benzenesulfonamide 
• 63366-76-7 (toluene-4-sulfonylamino)acetic acid benzyl ester 
• 79-20-9 acetic acid methyl ester 
• 941-55-9 4-toluenesulfonyl azide 
• 36850-80-3 [(1-methoxyvinyl)oxy]trimethylsilane 
• 18522-92-4 sodium p-toluenesulfonamide 
• 1738-68-7 Gly-OBz 
• 104-15-4 toluene-4-sulfonic acid 
• 61985-23-7 methyl 1-imidazolecarboxylate 
• 21978-63-2 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate 

Downstream Products

• 99069-24-6 N-nitroso-N-(toluene-4-sulfonyl)-glycine methyl ester 
• 100371-35-5 p-toluenesulfonylglycine isopropyl ester 
• 100129-93-9 N-(toluene-4-sulfonyl)-glycine-(2-chloro-ethyl ester) 
• 125700-20-1 α-methoxy-N-(4-toluenesulphonyl)-glycine methyl ester 
• 59724-90-2 (toluene-4-sulfonylimino)-di-acetic acid dimethyl ester 
• 20158-69-4 2-(N-benzyl-4-methylphenylsulfonamido)acetic acid 
• 198056-62-1 methyl N-(2-cyclopropylideneethyl)-N-tosylglycinate 
• 244168-28-3 4-methylphenylsulfonamido-N-methoxy-N-methylacetamide 
• 566883-82-7 N-(o-methylbenzyl)-N-(p-toluenesulfonyl)glycine methyl ester 
• 566883-81-6 N-(p-methylbenzyl)-N-(p-toluenesulfonyl)glycine methyl ester 
• 769923-44-6 [(2-cyclopropylidene-propyl)-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester 
• 769923-41-3 [(2-cyclopropylidene-1-methyl-ethyl)-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester 

Relevant articles and documents

A practical method for N-cyanation of secondary amines and sulfonamides

Cyanamides are an important class of molecules. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1, 2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.

Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications

Herein we report a catalyst- and metal-free visible-light-mediated protocol enabling the iodoamination of miscellaneous olefins. This protocol is characterized by high yields under environmentally benign reaction conditions utilizing commercially available substrates and a green and biodegradable solvent. Furthermore, the protocol allows for late-stage functionalization of bioactive molecules and can be scaled to gram quantities of product, which offers manifold possibilities for further transformations, including morpholine, piperidine, pyrrolidine, and aziridine synthesis.

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.