2646-38-0 Usage
Description
CHENODEOXYCHOLIC ACID SODIUM, a bile acid, is a sodium salt derivative of chenodeoxycholic acid. It is a solid substance that plays a crucial role in the emulsification and absorption of dietary fats. Its unique chemical properties allow it to interact with various bioactive molecules, making it a valuable compound for research and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
CHENODEOXYCHOLIC ACID SODIUM is used as a pharmaceutical compound for its ability to aid in the absorption and emulsification of dietary fats. It is particularly useful in the treatment of certain digestive disorders and conditions related to fat metabolism.
Used in Research and Development:
CHENODEOXYCHOLIC ACID SODIUM is used as a research compound for studying the interaction between dietary bioactive peptides of short length and bile salts in submicellar or micellar state. This helps in understanding the role of bile acids in fat digestion and absorption, as well as their potential therapeutic applications.
Used in Rat Hepatocyte Studies:
In the field of cellular and molecular biology, CHENODEOXYCHOLIC ACID SODIUM is used as a bile acid in rat hepatocyte studies. These studies are essential for understanding the role of bile acids in liver function and their potential impact on various metabolic processes.
Check Digit Verification of cas no
The CAS Registry Mumber 2646-38-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,4 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2646-38:
(6*2)+(5*6)+(4*4)+(3*6)+(2*3)+(1*8)=90
90 % 10 = 0
So 2646-38-0 is a valid CAS Registry Number.
InChI:InChI=1/C24H40O4.Na/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26;/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28);/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-;/m1./s1
2646-38-0Relevant articles and documents
Synthesis, characterization and biological activity of hydroxyl- bisphosphonic analogs of bile acids
Bortolini, Olga,Fantin, Giancarlo,Fogagnolo, Marco,Rossetti, Stefano,Maiuolo, Loredana,Di Pompo, Gemma,Avnet, Sofia,Granchi, Donatella
experimental part, p. 221 - 229 (2012/07/28)
Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of these pharmaceutically important molecules, including an evaluation of affinity and the mechanism of binding to hydroxyapatite, is presented. The biological activity of bile acid-containing bisphosphonate salts was determined using the neutral-red assay on the L929 cell line and primary cultures of osteoclasts. The bioactivity of the new compounds was found superior than bisphosphonates of established activity.
A process for the preparation of cholanic acids
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Page/Page column 3, (2010/11/30)
A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.