26475-62-7 Usage
General Description
4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE, also known as VESTA COR, is a chemical substance often utilized in various industrial applications. This chemical is notable for its structure consisting of a morpholine ring, a thioether, and a dioxolane ring, which collectively contribute to its properties and uses. It possesses a hydroxyl group, making it capable of forming hydrogen bonds and, hence, useful in certain chemical reactions. The detailed properties such as its boiling point, melting point, flash point and stability depend on its purity and other conditions. Like most chemicals, it must be handled with care, following standard safety guidelines to prevent possible hazards. Potential risks and safety measures should always be considered during its use. Detailed information can be found on its Material Safety Data Sheet.
Check Digit Verification of cas no
The CAS Registry Mumber 26475-62-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,4,7 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 26475-62:
(7*2)+(6*6)+(5*4)+(4*7)+(3*5)+(2*6)+(1*2)=127
127 % 10 = 7
So 26475-62-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO3S/c8-4-1-7-2-5-11(9,10)6-3-7/h8H,1-6H2
26475-62-7Relevant articles and documents
Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
Strotman, Neil A.,Tan, Yichen,Powers, Kyle W.,Soumeillant, Maxime,Leung, Simon W.
, p. 721 - 727 (2018)
Continuous processing enabled the highly energetic double conjugate addition of ethanolamine to divinylsulfone to prepare 2 kg of 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide, as an intermediate in the synthesis of HIV Maturation Inhibitor BMS-955176. In situ IR was employed to monitor the steady state of the transformation for increased robustness via appearance of the thiomorpholine dioxide moiety and disappearance of the divinylsulfone. Surprisingly, a series of oligomers formed as intermediates, which converted to product with extended aging or heating, consistent with computational predictions. By running this process in flow, the highly exothermic reaction could be safely executed in an equal volume of water as the only solvent, despite an adiabatic temperature rise of 142 °C, leading to a streamlined and efficient process.
