26478-11-5

Basic information

• Product Name: 12b-(4-chlorobenzyl)-2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one
• Synonyms: 12b-(4-chlorobenzyl)-2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one
• CAS NO: 26478-11-5
• Molecular Weight: 419.908
• Mol File: 26478-11-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 12b-(4-chlorobenzyl)-2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 12b-(4-chlorobenzyl)-2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one(26478-11-5)
• EPA Substance Registry System: 12b-(4-chlorobenzyl)-2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one(26478-11-5)

Safety Data

• Hazardous Substances Data: 26478-11-5(Hazardous Substances Data)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 53242-76-5 2‐(4-chlorophenylacetyl)benzoic acid 

Relevant articles and documents

Diverse privilegedN-polycyclic skeletons accessed from a metal-free cascade cyclization reaction

An exquisite metal-free cascade cyclization reaction of 2-acylbenzoic acids with amines was developed, which provided a powerful method for the one-pot synthesis of diverse isoindoloisoquinoline and benzoindolizinoindole derivatives. This protocol avoided the use of metal catalysts, proceeded with high efficiency and had broad substrate scope. These resulting products could be transformed into tertiary amines under the reduction of LiAlH4/AlCl3, followed by the Hofmann elimination offering lots of nitrogen-containing nine-membered ring compounds in excellent yields. All synthesized products containing fusedN-polycyclic skeletons were difficult to be constructed using traditional methods and they have a wide range of applications in the pharmaceutical area.