2654-12-8

Basic information

• Product Name: 1H-Imidazo[4,5-b]pyridine, 2-(phenylmethyl)-
• CAS NO: 2654-12-8
• Molecular Formula: C13H11N3
• Molecular Weight: 209.25
• Mol File: 2654-12-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Imidazo[4,5-b]pyridine, 2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazo[4,5-b]pyridine, 2-(phenylmethyl)-(2654-12-8)
• EPA Substance Registry System: 1H-Imidazo[4,5-b]pyridine, 2-(phenylmethyl)-(2654-12-8)

Safety Data

• Hazardous Substances Data: 2654-12-8(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Contains

Imidazole and pyridine rings

Substituent

Phenylmethyl group

Effect of substituent

Adds versatility to its chemical properties

Usage

Synthesis of pharmaceuticals and agrochemicals

Role in synthesis

Building block for more complex organic molecules

Importance

Unique structure and reactivity, valuable in the field of organic chemistry.

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 98-86-2 acetophenone 
• 102-04-5 1,3-Diphenylpropanone 
• 103-82-2 phenylacetic acid 
• 5442-34-2 ethyl 2-phenylacetimidate hydrochloride 

Downstream Products

• 56291-46-4 2-benzoyl-1H-imidazo<4,5-b>pyridine 

Relevant articles and documents

Microwave-assisted one step high-throughput synthesis of benzimidazoles

One-pot synthesis of benzimidazoles from diamines and carboxylic acids was developed under microwave irradiation condition, which provided a practical and efficient method for high-throughput synthesis of this important class of heterocyclic compounds.

Synthesis and evaluation of gastroprotective and antiulcer activity of some 2-substituted-1H-imidazo[4,5-b] pyridines and -1H-benzimidazoles

Several compounds possessing imidazo[4,5-b]pyridine and benzimidazole structure bearing substituents in position 2 were prepared in order to evaluate an anti-ulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole. Among

Heterocyclisation via Selective Elimination: Reaction of 2,3-Diaminopyridine with Acyclic Ketones under Thermal Conditions

Reactions of 2,3-diaminopyridine and its 5-bromo analogue with three symmetrical and nine unsymmetrical acyclic ketones under thermal conditions have been studied.The reactions have yielded 2-substituted-1H-imidazopyridines by the elimination of one of the C2-substituents from the probable, though unisolated, intermediates 2,2-disubstituted-2,3-dihydro-1H-imidazopyridine derivatives.Elimination of one of the groups in the case of symmetrical ketones and preferentially of benzyl group in the case of benzyl methyl ketone has been observed.All the three alkyl phenyl ketones studied afford 2-phenylimidazopyridine by the selective loss of the alkyl group.Elimination of branched alkyl group has been noticed in the reactions involving methyl t-butyl and methyl i-propyl ketones, while the preferential elimination of methyl group is observed in the case of methyl n-alkyl ketones.Suitable explanations have been offered for the observed selective eliminations.