265975-36-8

Basic information

• Product Name: Ethanone, 1-[2,4,6-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-
• CAS NO: 265975-36-8
• Molecular Formula: C26H50O4Si3
• Molecular Weight: 510.937
• Mol File: 265975-36-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2,4,6-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2,4,6-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-(265975-36-8)
• EPA Substance Registry System: Ethanone, 1-[2,4,6-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-(265975-36-8)

Safety Data

• Hazardous Substances Data: 265975-36-8(Hazardous Substances Data)

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 139140-13-9 1-{4-[(tert-butyldimethylsilyl)oxy]-2,6-dihydroxyphenyl}ethan-1-one 

Relevant articles and documents

Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, in Vitro and in Vivo Investigations of Jamunones

Twenty-three natural jamunone analogues along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the methyl group on chromanone affected the selectivity of molecules against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (JM) was screened as the most effective anti-triple-negative breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.

Selective cleavage of tert-butyldimethylsilylethers ortho to a carbonyl group by ultrasound

A general method for the selective cleavage of tert- butyldimethylsilylethers ortho to a carbonyl group is established by sonication of a 0.1 M solution of the substrate in 1/1 (v/v) CH3OH/CCl4. Other phenolic tert-butyldimethylsilylethers are unaffected. This reaction performed on flavanoids is completed within 3 h and no special workup is required. Other substrates are also investigated and a mechanism is proposed. (C) 2000 Elsevier Science Ltd.