267413-29-6

Basic information

• Product Name: 1-Methyl-1H-indazole-6-carbonitrile
• Synonyms: 1-Methyl-1H-indazole-6-carbonitrile;6-Cyano-1-methyl-1H-indazole
• CAS NO: 267413-29-6
• Molecular Formula: C9H7N3
• Molecular Weight: 157
• Mol File: 267413-29-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 321.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: -0.50±0.30(Predicted)
• CAS DataBase Reference: 1-Methyl-1H-indazole-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-indazole-6-carbonitrile(267413-29-6)
• EPA Substance Registry System: 1-Methyl-1H-indazole-6-carbonitrile(267413-29-6)

Safety Data

• Hazardous Substances Data: 267413-29-6(Hazardous Substances Data)

Usage

Structure

A derivative of indazole, containing a bicyclic structure with a benzene ring fused to a pyrazole ring.

Usage

Synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Physical appearance

White to off-white solid.

Molecular weight

161.17 g/mol.

Potential applications

Development of new drugs and biological research.

Unique properties

Chemical and biological properties that contribute to its potential use in various applications.

Upstream product

• 141290-59-7 1H-indazole-6-carbonitrile 
• 74-88-4 methyl iodide 
• 590417-94-0 6-bromo-1-methyl-1H-indazole 

Downstream Products

• 1620816-67-2 1-methyl-3-phenyl-1H-indazole-6-carbonitrile 
• 1620816-69-4 1-methyl-3,7-diphenyl-1H-indazole-6-carbonitrile 

Relevant articles and documents

FACTOR XIIA INHIBITORS

This invention relates to compoundsof formula (I)and methods of treatment using the compounds. The invention also relates to processes and methods for producing the compounds of the invention. The compounds of the invention are modulators of Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.

Palladium-catalyzed direct C7-arylation of substituted indazoles

A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K 2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave the expected products in good isolated yields. In addition, a one-pot Suzuki-Miyaura/ arylation procedure leading to C3,C7-diarylated indazoles has been developed.