26759-46-6

Basic information

• Product Name: Methyl 2-amino-4,5-dimethoxybenzoate
• Synonyms: 2-AMINO-4,5-DIMETHOXYBENZOIC ACID METHYL ESTER;2-AMINO-4,5-DIMETHOXY METHYL BENZOATE;4,5-DIMETHOXYANTHRANILIC ACID METHYL;4,5-DIMETHOXYANTHRANILIC ACID METHYL ESTER;6-AMINOVERATRIC ACID METHYL ESTER;METHYL 6-AMINO-3,4-DIMETHOXYBENZOATE;METHYL 6-AMINOVERATRATE;METHYL 4,5-DIMETHOXYANTHRANILATE
• CAS NO: 26759-46-6
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.21
• EINECS: 247-967-7
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Esters;Organic acids
• Mol File: 26759-46-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 130-134 °C
• Boiling Point: 343.1 °C at 760 mmHg
• Flash Point: 166.2 °C
• Appearance: /
• Density: 1.189 g/cm³
• Vapor Pressure: 7.19E-05mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.68±0.10(Predicted)
• BRN: 2724754
• CAS DataBase Reference: Methyl 2-amino-4,5-dimethoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-amino-4,5-dimethoxybenzoate(26759-46-6)
• EPA Substance Registry System: Methyl 2-amino-4,5-dimethoxybenzoate(26759-46-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25-22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 26759-46-6(Hazardous Substances Data)

Usage

Chemical Properties

Brown crystalline powder

InChI:InChI=1/C10H13NO4/c1-13-8-4-6(10(12)15-3)7(11)5-9(8)14-2/h4-5H,11H2,1-3H3

Upstream product

• 26791-93-5 methyl 4,5-dimethoxy-2-nitrobenzoate 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 67-56-1 methanol 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 93-07-2 Veratric acid 
• 350228-61-4 methyl 4,5-dimethoxy-2-(methylamino)-benzoate 

Downstream Products

• 496872-79-8 2-butyrylamino-4,5-dimethoxy-benzoic acid methyl ester 
• 17667-32-2 methyl 6-bromo-3,4-dimethoxybenzoate 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 855648-83-8 4,5-dimethoxy-2-(2-methoxycarbonyl-acetylamino)-benzoic acid methyl ester 
• 135509-75-0 2-(3-benzoyl-thioureido)-4,5-dimethoxybenzoic acid methylester 
• 134241-04-6 2-(3-acetyl-thioureido)-4,5-dimethoxybenzoic acid methylester 
• 853995-67-2 methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4,5-dimethoxyanthranilate 
• 16175-67-0 2-amino-6,7-dimethoxyquinolizin-4(3H)-one 
• 172301-59-6 6-(N-ethylamino)veratric acid methyl ester 
• 35241-23-7 6,7-dimethoxy-2-methylquinazoline-4(3H)-one 
• 169778-85-2 2-[4-Chloro-[1,2,3]dithiazol-(5Z)-ylideneamino]-4,5-dimethoxy-benzoic acid methyl ester 
• 184036-04-2 N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4,5-dimethoxy-2-methoxycarbonylphenyl)aminocarbonyl]thiophene-3-sulfonamide 
• 13794-72-4 3H-6,7-dimethoxyquinazolin-4-one 

Relevant articles and documents

PDIA4 INHIBITORS AND USE THEREOF FOR INHIBITING ?-CELL PATHOGENESIS AND TREATING DIABETES

Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS

The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathi