26766-19-8

Basic information

• Product Name: α,α-bisphenyl-5-pyrimidinemethanol
• Synonyms: α,α-bisphenyl-5-pyrimidinemethanol
• CAS NO: 26766-19-8
• Molecular Weight: 262.311
• Mol File: 26766-19-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: α,α-bisphenyl-5-pyrimidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-bisphenyl-5-pyrimidinemethanol(26766-19-8)
• EPA Substance Registry System: α,α-bisphenyl-5-pyrimidinemethanol(26766-19-8)

Safety Data

• Hazardous Substances Data: 26766-19-8(Hazardous Substances Data)

Upstream product

• 289-95-2 PYRIMIDINE 
• 119-61-9 benzophenone 
• 4595-59-9 5-bromopyrimidine 

Downstream Products

• 26766-56-3 C₁₇H₁₃ClN₂ 
• 1277164-75-6 5'-[diphenyl(5-pyrimidyl)methyl]-2'-deoxyuridine 
• 1277164-76-7 5'-[diphenyl-(5-pyrimidyl)methyl]amino-2',5'-dideoxyuridine 

Relevant articles and documents

DUTPASE INHIBITORS

Deoxyuridine derivatives of the formula (I) where R1 is H or various substituents; D is -NHCO-, -CONH-, -0-, -C(=O)-, -CH=CH, -CΞC-, -NR5-; R4 is hydrogen or various substituents; R5 is H, C1-C4 alkyl, C1-C4 alkanoyl; E is Si or C; R6, R7 and R8 are independently selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl or a stable monocyclic, bicyclic or tricyclic ring system; G is -O-, -S-, -CHR10-, -C(=O)-; J is -CH2-, or when G is CHR10 may also be -O- or -NH-; R10 is H, F, -CH3, -CH2NH2, -CH2OH; -OH R11 is H, F, -CH3, -CH2 NH2, -CH2OH, CH(OH)CH3, CH(NH3)CH3; or R10 and R11 together define an olefinic bond, or together form a -CH2-group, thereby defining a cis or trans cyclopropyl group; have utility in the prophylaxis or treatment of protozoal diseases such as malaria.

Biological evaluation of 5-substituted pyrimidine derivatives as inhibitors of brassinosteroid biosynthesis

A series of 5-substituted pyrimidine derivatives was synthesized, and their ability to inhibit brassinosteroid biosynthesis was tested. The biological activity of these compounds was evaluated by the cress stem elongation method. Among the synthesized com

Aromatase Inhibition by 5-Substituted Pyrimidines and Dihydropirimidines

The inhibition of estrogen biosynthesis has been suggested to be an effective treatment of hormone-dependent diseases, particularly breast cancer.Several series of 5-substituted pyrimidine derivatives have been synthesized and tested for their ability to inhibit the enzyme aromatase (estrogen synthetase).Compounds were evaluated in an in vitro assay that measured the inhibition of rat ovarian microsomal aromatase activity.Greatest inhibitory activity was achieved in the cases of diarylpyrimidinemethanols and diarylpyrimidinyl methanes which were substituted in the 4- and 4'-positions with electron-withdrawing substituents, particularly Cl.